research First-In-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
MK-2206 was safe and effectively blocked AKT signaling in cancer patients, warranting more trials.
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research Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes
BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.
research The Long-Term Effect of Specific Type II 5alpha-Reductase Inhibition with Finasteride on Bone Mineral Density in Men: Results of a 4-Year Placebo Controlled Trial
research Rosemary Oil vs Minoxidil 2% for the Treatment of Androgenetic Alopecia: A Randomized Comparative Trial
Rosemary oil and minoxidil 2% both effectively increase hair count in people with androgenetic alopecia, but rosemary oil causes less scalp itching.
research Bariatric Surgery for Spontaneous Ovulation in Women with Polycystic Ovary Syndrome: The BAMBINI Multicentre, Open-Label, Randomised Controlled Trial
Bariatric surgery improves ovulation rates in women with PCOS and obesity better than medical therapy.
research Randomized Trial of Microneedling Combined With 2% Minoxidil Topical Solution for the Treatment of Female Pattern Hair Loss in a Chinese Population
Combining microneedling with 2% minoxidil is more effective and safe for treating female pattern hair loss than using minoxidil alone.
research Safety and Tolerability of Low Dose Oral Minoxidil Monotherapy in Female Pattern Hair Loss: A Retrospective Review With Longitudinal Ambulatory Blood Pressure Monitoring
Low dose oral minoxidil is generally safe and can improve hair loss in women, with some experiencing side effects and minimal blood pressure changes.
research A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Assess the Efficacy of a Nutritional Supplement in Female Androgenic Alopecia
The nutritional supplement Pilopeptan® WOMAN improved hair growth and thickness in women with hair loss.
research Faculty Opinions Recommendation of Sublingual Minoxidil for the Treatment of Male and Female Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase 1B Clinical Trial
research Faculty Opinions Recommendation of Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Multicenter Trial
Low-level light therapy significantly increased hair density and thickness in people with hair loss, but they didn't notice a difference.
research A Double Blind, Randomised, Vehicle-Controlled, Safety and Tolerance Study of Topical PSK 3841 Solution at 5% Administered Twice Daily Over Four Weeks to Healthy Caucasian Males with Androgenetic Alopecia
research Faculty Opinions Recommendation of a Randomized, Single-Blind Trial of 5% Minoxidil Foam Once Daily Versus 2% Minoxidil Solution Twice Daily in the Treatment of Androgenetic Alopecia in Women
5% minoxidil foam used once daily is as effective as 2% minoxidil solution used twice daily for hair loss in women, but with fewer side effects like itching and dandruff.
research Comparison of Clinical Trials with Finasteride and Dutasteride
research Safety of Skin Care Products During Pregnancy
Most skin care products are safe during pregnancy, but avoid hydroquinone and tretinoin.
research A Randomized, Placebo-Controlled Trial of 1% Topical Minoxidil Solution in the Treatment of Androgenetic Alopecia in Japanese Women
1% topical minoxidil solution significantly improved hair growth in Japanese women with androgenetic alopecia, with no major side effects.
research Use of Cosmeceuticals During Pregnancy and Lactation
Use of cosmeceuticals during pregnancy and breastfeeding is not recommended due to insufficient safety data.
research Dermatology
Skin diseases are common and can significantly affect people's lives; better outcome measures and ethical clinical trials are needed to improve dermatology care.
research Implementing Patient Safety and Quality Improvement in Dermatology: Part 1 - Patient Safety Science
The document concludes that improving patient safety and quality is increasingly important in dermatology.
research Tolerance and Safety Profile of Sublingual Minoxidil in the Treatment of Androgenic Alopecia
Sublingual minoxidil is a safe and effective treatment for hair loss, especially in women.
research Safety of Antiandrogens for the Treatment of Female Androgenetic Alopecia with Respect to Gynecologic Malignancies
Spironolactone is safe for treating female hair loss, but the safety of other drugs is uncertain.
research Uncovering Shortcomings in Advertising Strategies for Over-The-Counter Minoxidil Products on Amazon
Most minoxidil products on Amazon don't provide safety or side effect information.
research Safety and Efficacy of Hair Growth Promoting Product in Adult Human Subjects With Alopecia
The hair growth product was effective and safe, increasing hair growth, thickness, and density while reducing hair fall.
research Topical 5% Minoxidil Versus Combined Erbium YAG Laser and Topical 5% Minoxidil in Androgenetic Alopecia: A Randomized Controlled Trial
Using a laser with minoxidil was more effective for hair loss than minoxidil alone.
research Faculty Opinions Recommendation of Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients
research Combined Microneedling With Topical Vitamin D3 or Bimatoprost Versus Microneedling Alone in the Treatment of Alopecia Areata: A Comparative Randomized Trial
Combining microneedling with either vitamin D3 or bimatoprost improves hair regrowth more than microneedling alone.
research Faculty Opinions Recommendation of Safety of Low-Dose Oral Minoxidil for Hair Loss: A Multicenter Study of 1404 Patients
research Safety and Efficacy of the Coadministration of Sildenafil and Finasteride
Taking sildenafil and finasteride together is safe and improves urinary and sexual symptoms in BPH patients.
research Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened
The topical inhibitor CUR61414 was not effective in treating basal cell carcinoma in human trials.
research Azathioprine
Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.
research Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series
Combining DPCP and anthralin helps regrow hair in some alopecia areata patients.