12 citations
,
July 2019 in “Veterinary Dermatology” The study suggests that nestin-expressing progenitor cells can differentiate into outer root sheath keratinocytes in hair follicles, indicating distinct progenitors for different hair follicle and epidermal components.
12 citations
,
July 2016 in “Forensic science international” This study found that postmortem root banding in hair is likely due to the degradation of the intermacrofibrillar matrix in the cortex, with no damage to the cuticle observed.
12 citations
,
January 2013 in “Acta Histochemica” Junctional proteins stabilize the inner root sheath and connect the companion layer in human hair.
12 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that hair follicle cells' growth in vitro is influenced by the concentration of androgens and antiandrogens, with papilla cells and outer root sheath keratinocytes showing distinct sensitivity.
11 citations
,
February 1982 in “RePub (Erasmus University, Rotterdam)” This review discusses the evolution of hair plucking techniques for diagnosing hair disorders and suggests uniform methods could improve consistency in evaluating hair growth and treatment.
10 citations
,
October 2000 in “PubMed” This study found that transgenic mice expressing HPV E6/E7 in the outer root sheath experience continuous hair follicle cycling due to delayed catagen entrance and insensitivity to telogen resting signals.
10 citations
,
October 1993 in “Archives of dermatological research” The researchers reported that the antipsoriatic compounds 1,25-dihydroxy-vitamin D3 and calcipotriol thinned the living cell compartment in organotypic ORS cultures by accelerating the differentiation pathway rather than affecting proliferation.
9 citations
,
June 2020 in “Tissue Engineering and Regenerative Medicine” This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.
9 citations
,
June 2019 in “Mycopathologia” This study found that the presence of Malassezia fungi in the scalp's hairy roots was more pronounced in individuals with androgenetic alopecia than in healthy controls, suggesting a potential link to the condition.
9 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the in vitro growth of hair follicle cells, particularly papilla cells and outer root sheath keratinocytes, is influenced by different concentrations of androgens and antiandrogens.
9 citations
,
October 1991 in “Archives of Dermatological Research” Testosterone, DHT, and estradiol significantly affect hair cell growth.
8 citations
,
March 2019 in “Journal of Biomedical Materials Research Part A” This laboratory study found that collagen matrices with high-sulfated hyaluronan may enhance the cultivation of human keratinocytes and melanocytes from hair follicles for epidermal graft development.
8 citations
,
May 2005 in “The American journal of dermatopathology/American journal of dermatopathology” This study observed unique ultrastructural changes in a 4-year-old girl with pili trianguli et canaliculi that may affect hair shaft surface characteristics due to inner root sheath alterations.
8 citations
,
July 2004 in “Journal of morphology” This study explored the structure and keratin composition of marsupial hairs, finding similarities in keratin localization to hairs in placental mammals, and highlighting potential roles of trichohyalin and transglutaminase during hair development and shedding.
7 citations
,
July 2016 in “Journal of Biomedical Materials Research Part A” This study found that a novel hydrogel scaffold, cGEL, significantly increased melanin production and melanotic gene expression in human melanocytes compared to other graft materials, suggesting its potential as a superior carrier for skin grafting.
7 citations
,
February 2013 in “Tropical Journal of Pharmaceutical Research” In this study, applying G. glabra root extract to female rats resulted in faster and more extensive hair growth than minoxidil or a control treatment.
7 citations
,
December 2011 in “Annals of anatomy” This study found that involucrin likely plays a key role in forming the cornified material of the medulla and inner root sheath of human hair, contributing to its mechanical strength.
6 citations
,
December 2018 in “The American Journal of Dermatopathology” This study found that the presence of premature desquamation of the inner root sheath in noninflamed hair follicles is a relatively specific marker for diagnosing central centrifugal cicatricial alopecia.
6 citations
,
December 1990 in “PubMed” This study examined the expression patterns of various cytokeratins in the outer root sheath of human anagen hair follicles, noting distinct differentiation patterns and localization of keratin markers.
6 citations
,
May 1987 in “Acta dermato-venereologica” In this study, analysis of hair root status showed similar abnormalities in both primary and secondary syphilis patients, though it remains unclear if these are specific to syphilis.
5 citations
,
September 2012 in “BMJ case reports” This case study reports that a woman with non-classical adrenal hyperplasia who self-treated with Ashwagandha for six months experienced biochemical improvements and reduced scalp hair loss.
5 citations
,
August 2012 in “Journal of Dermatology” This report presents a case where female pattern hair loss might be linked to tamoxifen use, with increased androgen receptor expression observed in the affected scalp area.
5 citations
,
January 2012 in “Journal of Tissue Science & Engineering” In this study, collagen I decellularized scaffolds enhanced the growth and melanotic properties of hair follicle melanocytes, suggesting their potential as effective carriers for transplantation in vitiligo treatment.
4 citations
,
April 1989 in “The Journal of Dermatology” This study observed in mouse skin that trichohyalin granules in hair follicles transform into filamentous structures as inner root sheath cells differentiate and cornify.
3 citations
,
November 2019 in “Journal of Investigative Dermatology” In this study, researchers reported that adenosine stimulated hair shaft elongation in cultured human hair follicles by promoting proliferation and prolonging the anagen phase, suggesting the A2B adenosine receptor in outer root sheath keratinocytes as a promising target for treating hair growth disorders like alopecia.
3 citations
,
October 1994 in “Journal of Dermatological Science” This study developed a novel monoclonal antibody, TYHF-1, which specifically reacts with hair keratins but not with epidermal keratins or various other tissue cells.
2 citations
,
July 2021 in “Genes” This study identified a new genetic variant in the KRT71 gene responsible for a breed-specific form of hypotrichosis in Hereford cattle, potentially serving as a model for similar human conditions.
2 citations
,
August 2017 in “Experimental Dermatology” This study developed a new melanocyte cultivation medium without chemical mitogens, melanogenesis enhancers, or bovine products, demonstrating successful proliferation and melanotic differentiation of human melanocytes from hair follicles.
2 citations
,
January 2017 in “Case reports in endocrinology” This report describes an elderly woman whose nonclassic 11-hydroxylase deficiency, presenting as acne and male pattern alopecia, may have been ameliorated by Ashwagandha root in a dose-related manner.
2 citations
,
July 2004 in “Cell Biology International” This study found that urokinase plasminogen activator (uPA) is elevated in hyperproliferative hair follicle keratinocytes in mice, and its inhibition significantly reduces their proliferation.