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In this study with organ-cultured human scalp hair follicles, high mTORC1 activity correlated with gray/white hair and reduced pigmentation, while inhibiting mTORC1 with rapamycin increased hair growth and pigmentation, suggesting mTORC1 inhibition could be a strategy for treating hair depigmentation and loss.

The researchers observed that vitiligo-affected skin shows a selective depletion of NTRK2+ melanocyte subpopulations with progenitor features, which may contribute to poor treatment responses.

This study described the safety profile of tyrosine kinase inhibitors in treating various solid tumors, finding that the observed toxicities were consistent with existing literature.

This article reviews various "white diseases" characterized by hypopigmentation or depigmentation and emphasizes the role of melanosomes in skin and eye color, but it does not present new clinical results.

This review discusses the role of zinc in skin physiology related to vitiligo and reports no new clinical results; the authors emphasize its potential in pathogenesis and treatment.

This study suggests that varicella-zoster virus infection in skin cells may play a role in segmental vitiligo's progression and depigmentation.

This study found that hair plucking induced greying in castrated mice, suggesting that decreased androgen levels could play a role in age-related hair greying in humans.

This study describes a new mouse model for vitiligo that mimics key clinical features such as skin depigmentation and CD8 + T cell infiltration, providing a useful tool for in-depth research and drug discovery.

This review summarizes the historical and evolving treatments for vitiligo, highlighting that combining medical and surgical approaches may enhance repigmentation outcomes, though more research and new protocols are needed.

This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.

This scoping review reports that microneedling appears to be beneficial as an adjunctive therapy for cutaneous manifestations of autoimmune diseases like alopecia areata and vitiligo, improving outcomes when paired with other treatments, though evidence is limited and further research is needed.

This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.

This review discusses the increasing reports of rare cutaneous side effects from topical imiquimod, aiming to inform physicians and dermatologists about its potential adverse effects as its use expands.

Nutrition plays a key role in managing skin disorders, with specific dietary changes helping improve conditions like acne, dermatitis, psoriasis, alopecia, and skin cancer.

This systematic review examined 64 randomized controlled clinical trials on regenerative medicine for specific dermatologic disorders, reporting up to 68.4% improvement in androgenetic alopecia and up to 71% improvement in vitiligo among 2888 patients.

In this study, single hair grafting was reported to be an effective treatment for localized/segmental vitiligo, notably in hairy skin areas, with repigmentation observed in 82% of those cases.

This study found that Plerixafor, a CXCR4 antagonist, promotes melanogenesis in melanocytes by increasing MITF and tyrosinase expression and enhancing melanocyte migration, and it effectively restores pigmentation in a mouse depigmentation model without toxicity, highlighting its potential for treating pigmentary disorders.

This review examines the use of computer vision techniques, specifically deep learning architectures and image processing algorithms, for detecting and assessing skin conditions like vitiligo and dermatitis, and highlights the need for disease-specific datasets to improve automated diagnostic tools in dermatology.

This case report detailed a 45-year-old woman with diffuse systemic sclerosis who underwent Ayurvedic treatment, leading to reduced depigmentation, new hair growth, and improved well-being over eight weeks. The findings suggest the potential efficacy of a holistic Ayurvedic approach in managing scleroderma symptoms.

Hair follicle-derived melanocyte transplant could effectively treat vitiligo by restoring skin color.

This review highlights the varied therapeutic applications of punch-based techniques in dermatologic surgery, noting consistent evidence for follicular unit extraction in androgenetic alopecia, but more mixed results for scar treatment, vitiligo, and chronic wounds, warranting further standardized research.

This study observed that premature hair graying was more prevalent among obese individuals, those with vitamin B12 and D deficiencies, smokers, and people with high stress, regardless of whether they were medical or non-medical students at a university in Saudi Arabia.

This study found that specific dermoscopic signs, such as diameter diversity of leukotrichia and Pohl-Pinkus constrictions, were associated with progressive vitiligo, and early-stage melanin synthesis was impaired in vitiligo-associated leukotrichia.

This article highlights that early and high-dose corticosteroid therapy, along with immunosuppressive agents, is crucial for managing Vogt-Koyanagi-Harada disease, and emerging biological therapies may benefit refractory cases.

This review explores the complex biological process of hair graying, highlighting oxidative stress, genetic factors, and interventions like antioxidants and genetic therapy as key aspects affecting the preservation of hair pigmentation.

This review discusses the processes of melanocyte stem cell quiescence and activation, focusing on their interaction with hair follicle stem cells, and highlights current research on hair graying mechanisms; it reports no new results.

Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.

This article explores how various nutrients and metabolic processes impact wool and hair follicle function in animals but reports no new experimental findings.

This review discusses the wound healing process and the factors contributing to abnormal scarring after thermal injuries, but it reports no new clinical results.

In this study, an 18-year-old female with vitiligo underwent Pracchana Karma and Ayurvedic treatments, resulting in progressive skin re-pigmentation and improved quality of life without adverse effects.