13 citations
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March 1983 in “International Journal of Dermatology” Minoxidil caused red hair to grow on a man's temples.
19 citations
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November 2017 in “Journal of Pharmaceutical Sciences” This research investigated aqueous alginate-based hydrogels for delivering minoxidil and reported that using hydroxypropyl-β-cyclodextrin (HP-β-CD) with molar substitution 0.65 significantly enhanced minoxidil's solubility and skin permeability without damaging the epidermis, suggesting potential as an alternative to commercial minoxidil solutions.
4 citations
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January 1989 This case study reported that two patients treated for androgenetic alopecia with Regaine® solution developed allergic contact dermatitis due to propylene glycol, highlighting the importance of testing the vehicle in patch tests.
May 2025 in “International Journal of Pharmacognosy and Chemistry” This study developed and validated a simple, precise, and cost-effective UV spectrophotometric method for quantifying Minoxidil in bulk and pharmaceutical forms, reporting high accuracy with recovery rates between 99.57% and 100.55%, and a correlation coefficient of 0.9993.
2 citations
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July 2022 in “Journal of the American Academy of Dermatology” In this study, researchers aimed to evaluate the safety and tolerability of low-dose oral minoxidil in adolescents, as existing data on its use in this population are limited and there are no specific pediatric guidelines for prescribing it. Results are not reported.
July 2025 in “Journal of Investigative Dermatology” Low-dose oral minoxidil is safe for the heart in the short term for hair loss patients.
January 2026 in “National Journal of Pharmaceutical Sciences” This study developed and validated a Gas Chromatography-Flame Ionization Detection method for assessing minoxidil, which shows good precision, accuracy, and specificity for quality control and pharmacokinetic studies.
January 2005 in “Belarusian State Pedagogical University repository (Belarusian State Pedagogical University)” In this study, a 0.5% addition of TPGS to topical minoxidil solutions increased hair growth in mice, but higher concentrations reduced this benefit.
January 2026 in “International Journal of Molecular Sciences” This review highlights brimonidine’s potential as a dermatological agent, noting its ability to improve rosacea-related facial redness and its effectiveness in various other skin conditions due to its vasoconstrictive and anti-inflammatory actions, with minimal systemic absorption and a favorable safety profile for long-term use.
September 2022 in “JAAD Case Reports” This case report discusses rare but serious cardiac complications, including pericarditis and edema, observed with low-dose oral minoxidil for hair loss, highlighting the need for cautious prescribing, especially in high-risk patients.
June 2024 in “International Journal of Pharmaceutical Research and Applications” This study designed fast-dissolving Minoxidil tablets to improve patient compliance and found that formulations containing 6% croscarmellose sodium were optimal, showing rapid in-vitro dispersion and effective drug release without drug interaction.
July 2026 in “Journal of the American Academy of Dermatology” March 2025 in “International Journal of Trichology” This case report describes a 38-year-old woman who experienced significant hair loss known as anagen effluvium after accidentally ingesting Gloriosa superba tubers, a plant commonly found in tropical regions with high colchicine content.
11 citations
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April 2009 in “Pharmacotherapy” Minoxidil can cause deadly skin reaction; monitor patients closely.
November 2024 in “JAMA Dermatology” This consensus statement provides expert guidance on prescribing low-dose oral minoxidil for hair loss, noting a lack of representation of pediatric specialists and highlighting areas for future research.
In this descriptive retrospective study, researchers reported that low-dose oral minoxidil (0.25-5mg/day) for androgenic alopecia demonstrated a good safety profile, with 84.4% of 641 patients experiencing no adverse effects and only 1.4% discontinuing due to side effects that resolved with dose reduction or withdrawal.
March 2019 in “Reactions Weekly” 2 citations
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October 2021 in “Clinical and experimental dermatology” In this study, Cyperus rotundus essential oil was found to have significantly better depigmenting effects than hydroquinone for treating axillary hyperpigmentation, with additional benefits in reducing inflammation and hair growth, making it a cost-effective and safe treatment option.
45 citations
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January 1981 in “Annals of Internal Medicine” Minoxidil controls blood pressure effectively, but may cause side effects like hypertrichosis.
July 2022 in “Journal of Investigative Dermatology” This study found that a new alcohol-free minoxidil hydrogel formulation showed comparable in vitro efficacy and skin absorption to the commercial minoxidil product for treating androgenetic alopecia.
9 citations
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January 2013 in “Case reports in emergency medicine” This case study reports that Citrullus colocynthis can cause severe gastrointestinal symptoms, including rectorrhagia and mucosal erosion, highlighting the need for awareness of its potential side effects.
February 2020 in “Drug Analytical Research” This study found that magistral topical minoxidil solutions had differences in color, viscosity, and acidity compared to industrial formulations and issues with drug content and dosage indication, despite similar follicular penetration.
May 2018 in “European Journal of Dermatology” Adjusting the medication tacrolimus resolved a boy's red nail beds after a stem cell transplant.
18 citations
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October 2005 in “International Journal of Pharmaceutics” This study found that incorporating 0.5% TPGS into topical minoxidil solutions enhanced hair growth in mice, although increasing TPGS to 2% decreased effectiveness.
May 2026 in “Frontiers in Medicine” This study concluded that combining the Shumin treatment instrument with oral doxycycline provides better clinical outcomes for rosacea than combining red light therapy with doxycycline, while both regimens improved quality-of-life scores and reduced Demodex counts.
26 citations
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April 1977 in “PubMed” This report notes that five women experiencing hypertrichosis as a side effect of minoxidil had successful hair removal using a calcium thioglycolate depilatory agent.
33 citations
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May 1991 in “British Journal of Pharmacology” Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.
1 citations
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February 2022 in “Veterinární Medicína” This report presents the first successful management of minoxidil toxicosis in a cat, detailing the clinical progression and treatment plan used to resolve the condition.
August 2023 in “Dermatology Reports” This observational study from Saudi Arabia suggests that extended use of Minoxidil might lead to hair discoloration, especially among those with a family history of hair greying.
1 citations
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April 2025 in “Romanian Journal of Ophthalmology” This study indicates that central serous chorioretinopathy linked to topical minoxidil use is rare, suggesting the need for early detection and discontinuation if it occurs.