Topical Cyperus Rotundus Essential Oil for Treatment of Axillary Hyperpigmentation: A Randomized, Double-Blind, Active- and Placebo-Controlled Study

October 2021 in “ Clinical and experimental dermatology ”

Ghada Farouk Mohammed

Cyperus rotundus essential oil hydroquinone axillary hyperpigmentation depigmenting effects anti-inflammatory effects hair growth CREO HQ

TLDR Cyperus rotundus essential oil effectively treats underarm darkening, reduces inflammation, and slows hair growth.

The study evaluated the efficacy of Cyperus rotundus essential oil (CREO) for treating axillary hyperpigmentation compared to hydroquinone (HQ) and a placebo in a randomized, double-blind trial with 153 participants. Results showed that CREO had significantly better depigmenting effects than HQ (P < 0.001) and also demonstrated superior anti-inflammatory effects and a decrease in hair growth (P < 0.05). CREO was found to be a cost-effective and safe treatment option for axillary hyperpigmentation.

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Topical Cyperus Rotundus Essential Oil for Treatment of Axillary Hyperpigmentation: A Randomized, Double-Blind, Active- and Placebo-Controlled Study

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