Quality Evaluation of Minoxidil Topical Solutions Obtained from Magistral Pharmacies

February 2020 in “ Drug Analytical Research ”

Karen Nicolau Dartora, Paula Cristina Bona, Francielli Lima dos Santos, Paula Bianchetti, Renata Vidor Contri

minoxidil topical solutions ethanol follicular penetration drug content viscosity pH density Rogaine

TLDR Magistral pharmacies had issues with production quality and dosage accuracy.

The study evaluated the quality of magistral minoxidil topical solutions (A, B, and C) compared to an industrial formulation. Differences were found in color, viscosity, and pH, with magistral solutions being more acidic. Density varied with ethanol content, and only the industrial and magistral sample C met the expected drug content (90-110%). Dosages from magistral pharmacies were significantly lower than industrial recommendations. All solutions showed similar follicular penetration of minoxidil. The study concluded that magistral pharmacies had issues with production quality and dosage accuracy.

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