62 citations
,
December 1941 in “Experimental biology and medicine” In this study, phenylthiocarbamide intake was associated with hair graying in rats, while switching to tap water led some rats to regain their original fur color, suggesting dietary factors influence pigmentation.
3 citations
,
March 2021 in “Cureus” This article reports a rare combination of rapid-onset halo nevi, nonsegmental vitiligo, and premature scalp hair graying.
June 2026 in “Experimental Dermatology” This study found no strong genetic link between hair color and alopecia areata risk, although a weak inverse association with blond hair was suggested, noting the results are exploratory and require further investigation with larger cohorts.
June 2009 in “Pigment Cell & Melanoma Research” This review explores the role of oxidative stress and stem cell decline in hair graying, suggesting potential areas for future research but reports no new findings.
2 citations
,
September 2020 in “International journal of radiology & radiation therapy” This study describes changes in scalp hair color, including rare instances of repigmentation, following volumetric modulated arc therapy for skin cancer; this potential side effect may warrant discussion during informed consent.
41 citations
,
April 2019 in “PLOS genetics” This study found that CD34- melanocyte stem cells regenerated pigmentation more efficiently, while CD34+ cells showed potential for neuron myelination, suggesting different therapeutic applications for each population.
This study found a significant association between premature greying of hair and deficiencies in vitamin D, vitamin B12, hypothyroidism, and disrupted iron profiles, alongside lifestyle factors like stress and smoking.
5 citations
,
July 2017 in “International journal of endocrinology and metabolism/International journal of endocrinology and metabolism.” This study described the clinical and genetic features of two Iranian siblings with hereditary vitamin D resistant rickets, identifying a specific VDR gene mutation contributing to their symptoms.
1 citations
,
November 2019 in “International Journal of Women's Dermatology” Ketoconazole shampoo can cause rare pink hair discoloration.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” This study found that increased PHGDH expression in mice led to earlier melanin and melanocyte presence in hair follicles but did not induce cancer.
October 2024 in “Journal of Cosmetic Dermatology” This study in Saudi Arabia found that 55.9% of participants reported premature graying of hair before age 30, with risk factors including genetic, health, and lifestyle aspects such as smoking, anxiety, nutrient deficiencies, and family history.
June 2024 in “British Journal of Dermatology” In this case report, an 80-year-old woman experienced darkening of previously grey hair, which may be linked to vitamin B supplementation, though its effectiveness is typically associated with reversing greying only in the presence of an initial vitamin B deficiency.
44 citations
,
April 1979 in “Journal of Ultrastructure Research” January 2025 in “Figshare” This case report describes a 17-month-old girl who experienced sudden hair whitening during septic shock, suggesting systemic stress may trigger canities subita in young children and highlighting the need to distinguish it from congenital pigment dilution syndromes.
3 citations
,
December 2024 in “International Journal of Dermatology” This review examined the psychological effects, mechanisms, health associations, and treatments related to premature hair graying, highlighting factors like genetics, oxidative stress, smoking, and diet, with the aim of enhancing understanding and addressing its broader implications.
17 citations
,
February 2011 in “International Journal of Cosmetic Science” This study found that individual differences between pigmented and unpigmented hair fibers in Old Order Mennonites suggest grey hair may be perceived as drier and less manageable due to small mechanical and moisture changes.
June 2025 in “BMJ Case Reports” In this case report, researchers observed hair repigmentation in a man with metastatic renal cell carcinoma during treatment with axitinib, marking the first documented instance of this effect with axitinib without the use of hair dyes or other medications.
98 citations
,
November 2002 in “Contact Dermatitis” This study found that adverse reactions to para-phenylenediamine in hair dye, including severe allergic contact dermatitis, may be more common than currently reported and often misdiagnosed.
23 citations
,
August 2017 in “Scientific Reports” Darker hair may lead to higher cortisol readings, suggesting a need to adjust for hair color in studies.
May 2026 in “Clinical Cosmetic and Investigational Dermatology” This study observed that white hair can create an optical illusion of increased scalp visibility, potentially misleading clinical evaluations of hair loss and complicating hair transplantation planning, and identified five core dyeing strategies to address this phenomenon.
January 2015 in “프로그램북(구 초록집)” This study found that Korean Red Ginseng may protect against chemotherapy-induced alopecia by reducing hair follicle damage in a human hair follicle organ culture model.
6 citations
,
February 2016 in “International Journal of Dermatology” This review discusses historical and literary accounts of sudden hair whitening, known as canities subita, and presents no new clinical findings.
6 citations
,
January 2017 in “Journal of toxicologic pathology” This study suggests that the patchy thickening and reddish discoloration in rabbit skin during the hair cycle may be due to large anagen-phase hair follicles compressing the dermis and increased blood vessels causing redness.
72 citations
,
October 2010 in “Journal of The American Academy of Dermatology” This study concluded that iron deficiency is common among women but not more prevalent in those with female pattern hair loss or chronic telogen effluvium compared to control subjects without hair loss.
3 citations
,
November 2015 in “Endocrinology, Diabetes & Metabolism Case Reports” This case study reports a rare instance of RC11 associated with precocious puberty, severe hyperandrogenism, insulin resistance, and type 2 diabetes, suggesting a possible link to 11q-syndrome.
December 1990 in “PubMed” This review discusses various adverse drug reactions affecting hair, such as hair loss, hypertrichosis, and color changes, and emphasizes their generally reversible nature if the causative drug is discontinued.
8 citations
,
February 2007 in “Journal of The American Academy of Dermatology” This commentary critiques the definition of iron deficiency in hair loss studies, suggesting higher serum ferritin levels as a more accurate threshold for diagnosing deficiency in women.
8 citations
,
January 2009 in “Journal of pediatric endocrinology & metabolism/Journal of pediatric endocrinology and metabolism” This study reports a novel TRbeta gene mutation associated with resistance to thyroid hormone syndrome, which may contribute to various forms of alopecia in the affected family members.
December 2025 in “Sustainable Chemistry One World” In this study, researchers found that mangosteen pericarp extract, combined with FeSO₄ as a mordant, effectively produced a stable reddish hair dye on bleached hair, with good color persistence and enhanced tensile strength, indicating its potential as an eco-friendly and safer alternative to synthetic dyes.
February 2013 in “Journal of the American Academy of Dermatology” Iron supplements may reverse premature hair graying caused by iron deficiency.