January 2018 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identified a new cis-regulatory element in the mouse Hr gene that influences its expression in skin and brain cells, highlighting a complex molecular network involved in hair follicle formation.
12 citations
,
January 1994 in “Dermatology” This study found that a patient with giant axonal degeneration had unique hair abnormalities such as trichorrhexis nodosa and altered S:N ratios, unlike her relatives but comparable to unrelated controls.
17 citations
,
January 2018 in “International Journal of Trichology” This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.
5 citations
,
June 2015 in “Journal of dermatology” This letter to the editor describes a case of anagen effluvium due to thallium poisoning from Chinese herbal medicine and rodenticide but reports no new research findings.
152 citations
,
December 2003 in “Micron” This review discusses the development, regulation, and aging of the human hair follicle pigmentary system and suggests potential for reversing hair graying by manipulating follicle melanocytes in vitro, but reports no clinical results.
April 2012 in “Development” This study found that Rac1 activity in specific skin compartments is sufficient for hair formation, but results in hair with altered structure and pigmentation compared to normal.
November 2013 in “Institutional Repositories DataBase (IRDB)” In this study, γ-ray exposure in mice decreased hair follicle density and pigmentation, suggesting damage to stem cells affecting hair follicle regeneration.
2 citations
,
January 1972 In this study, plucked rat hair showed greater accumulation of injected radioisotopes than shaved hair, which may have implications for measuring exposure and understanding follicle tissue processes.
24 citations
,
August 2020 in “JAMA dermatology” In this study, researchers observed a dose-dependent occurrence of persistent radiation-induced alopecia in patients with primary CNS tumors or head and neck sarcomas, noting distinctive patterns and features, and suggesting potential benefits of topical minoxidil and procedural interventions for treatment.
8 citations
,
January 2018 in “European journal of dermatology/EJD. European journal of dermatology” The girl's regrown brown hair had less of certain pigments than her original black hair.
1 citations
,
October 2023 in “Skin Research and Technology” In this study, researchers found that while sunscreens added to hair products do not provide expected protection, the dark hair absorbs the most radiation across all wavelengths, indicating a need for enhanced protection.
12 citations
,
December 2017 in “Food and chemical toxicology” This study found that mixtures used in permanent hair dyes had irritant effects on reconstructed human epidermis, while individual ingredients alone did not.
January 2004 in “Giornale di Metafisica: revista bimestrale di filosofia” This study suggests that increased Wnt signaling may promote excessive differentiation of melanocytes, leading to exhaustion of melanocyte stem cells and hair graying in aged mice.
June 2024 in “Skin Research and Technology” In this study, researchers observed significant differences in microbial composition between UV-induced fluorescent and non-fluorescent scalp areas in patients with androgenetic alopecia, noting a higher abundance of Cutibacterium in the fluorescent regions.
6 citations
,
October 2012 in “Pediatrics” This case report describes an 11-year-old girl who experienced hot flashes and menarche after taking a Serenoa repens supplement for telogen effluvium, suggesting a possible but uncertain link between the supplement and hormonal changes.
4 citations
,
October 2003 in “Annales de Génétique” This study identified a mutation in the KRTHB6 gene in two monilethrix families of Indian origin, linking specific genetic variations to different severities of hair defects within the families.
Trichorrhexis nodosa causes hair to break easily, often affecting young to middle-aged black women.
7 citations
,
February 2019 in “International Journal of Dermatology” This review discusses factors influencing hair pigmentation and the etiology of canities, noting the lack of clarity in underlying mechanisms and calling for further research on treatment options.
April 2014 in “The FASEB Journal” This study found that maternal hephaestin knockout in mice leads to neonatal hair loss, likely due to low iron levels in the mother's milk.
9 citations
,
May 2013 in “JAMA Dermatology” This report details a case of extensive leukotrichia induced by dasatinib in a patient with refractory chronic myelogenous leukemia.
11 citations
,
December 2016 in “Frontiers in Psychology” In this study, researchers used computer-generated models to demonstrate that subtle changes in hair diameter, density, and style significantly affect perceptions of age, health, and attractiveness.
1 citations
,
June 2022 in “Experimental dermatology” This study found that SHJH hr mice, with a Hairless gene mutation, exhibit accelerated skin aging potentially due to poor antioxidative protection, highlighting the Hr gene's role in skin aging.
11 citations
,
September 2010 in “American Journal of Medical Genetics - Part A” This study reports a mutation in the U2HR gene causing Marie Unna hereditary hypotrichosis in a Turkish family and notes eyebrow loss as a diagnostic clue.
15 citations
,
September 2012 in “PTR. Phytotherapy research/Phytotherapy research” In this study, topical application of ginsenosides Rb₁ and Rd in mice increased cell proliferation in hair follicles, suggesting they may help prevent hair loss by promoting growth through p63 induction.
November 2025 in “Indian Journal of Nephrology” In this case study, a 43-year-old male with anti-GBM disease experienced a relapse triggered by hair dye, leading to diffuse alveolar hemorrhage; managing this with plasmapheresis, intravenous immunoglobulins, and rituximab suggests rituximab may be beneficial for relapsing cases.
December 2025 in “Applied and Computational Engineering” In this study, researchers explored the potential allergenicity and harmful effects of hair dyes, noting that adverse effects such as sensitization and potential carcinogenicity are not inevitable and can vary based on individual physiological differences.
26 citations
,
June 2016 in “Pediatric Dermatology” This study found that premature hair graying in young Turkish men and women is associated with emotional stress, alcohol consumption, chronic diseases, and a family history of graying.
98 citations
,
June 2008 in “Human mutation” This study found that a genetic variant in the EDAR gene leads to typical East Asian hair characteristics by increasing signaling output, as shown in transgenic mice experiments.
September 2006 in “Fertility and Sterility” This study found a positive association between higher birth weight and self-reported graying of hair in premenopausal infertile women.
6 citations
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January 2019 in “International Journal of Medicine in Developing Countries” This study found that premature greying of hair was reported in 42.5% of young adults from King Faisal University, with higher prevalence among females, and noted associations with various health and lifestyle factors.