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      Melatonin Membrane Receptors in Peripheral Tissues: Distribution and Functions

      research Melatonin membrane receptors in peripheral tissues: Distribution and functions

      506 citations , January 2012 in “Molecular and Cellular Endocrinology”
      This review details the expression and diverse functions of melatonin receptors in non-neural tissues and reports no new clinical findings, emphasizing their potential as therapeutic targets across various physiological and pathological processes.
      Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      research Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition

      451 citations , March 2005 in “Endocrine Reviews”
      This paper discusses the role of steroid sulfatase in hormone-dependent tumors and highlights the development of potent inhibitors, noting the commencement of a phase I trial for one inhibitor in postmenopausal breast cancer patients.
      Is Dehydroepiandrosterone a Hormone?

      research Is dehydroepiandrosterone a hormone?

      403 citations , November 2005 in “Journal of Endocrinology”
      This review discusses the role of DHEA in intracrinology, highlighting its impact on breast and prostate cancer treatment and potential as a menopause therapy, but reports no new research findings.
      The Neurobiology of Sexual Function

      research The Neurobiology of Sexual Function

      393 citations , November 2000 in “Archives of General Psychiatry”
      This review discusses the neurobiology of sexual function and reports no new results; the authors cover multiple endocrine and neurotransmitter influences on sexual desire, arousal, and orgasm stages.
      Environmental Factors and Puberty Timing: Expert Panel Research Needs

      research Environmental Factors and Puberty Timing: Expert Panel Research Needs

      284 citations , February 2008 in “Pediatrics”
      This review discusses the potential impact of endocrine-disrupting chemicals and body size on pubertal onset and progression, highlighting critical gaps and priorities for future research without presenting new clinical results.
      Genetic, Hormonal, and Metabolic Aspects of PCOS: An Update

      research Genetic, hormonal and metabolic aspects of PCOS: an update

      258 citations , July 2016 in “Reproductive Biology and Endocrinology”
      This abstract reviews the characteristics and health risks associated with polycystic ovary syndrome and does not report new findings, highlighting the syndrome's multifactorial nature.
      The Pathophysiology of Polycystic Ovary Syndrome

      research The pathophysiology of polycystic ovary syndrome

      249 citations , November 2003 in “Clinical endocrinology”
      This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.
      5α-Reductase Activity in the Prostate

      research 5α-reductase activity in the prostate

      237 citations , December 2001 in “Urology”
      This review discusses the role of 5α-reductase in prostate development and BPH, and reports no new clinical results; ongoing trials are exploring dual isozyme inhibitors for improved treatment efficacy.
      Is COVID-19 Gender-Sensitive?

      research Is COVID-19 Gender-sensitive?

      228 citations , January 2021 in “Journal of Neuroimmune Pharmacology”
      This review explores possible reasons for why male COVID-19 patients experience more severe symptoms and higher fatality rates than female patients but provides no new clinical results.
      Melatonin

      research MELATONIN

      220 citations , August 1988 in “Clinical endocrinology”
      This review provides a comprehensive overview of melatonin's physiological roles, effects, and clinical implications, but it does not present new experimental findings.
      Androgens and Hair Growth

      research Androgens and hair growth

      209 citations , September 2008 in “Dermatologic Therapy”
      This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.
      Adverse Effects of Opioid Analgesic Drugs

      research ADVERSE EFFECTS OF OPIOID ANALGESIC DRUGS

      183 citations , January 1987 in “British Journal of Anaesthesia”
      This article discusses the long-standing use and safety of opioids in anaesthesia, noting that respiratory depression is a manageable side effect due to the availability of opioid antagonists.
      Fetal Alcohol Syndrome: Current Status of Pathogenesis

      research Fetal Alcohol Syndrome: Current Status of Pathogenesis

      171 citations , October 1990 in “Alcoholism/Alcoholism, clinical and experimental research”
      The document concludes that the exact way alcohol causes harm to fetal development is unknown, but it significantly affects nutrient transport to the fetus and a safe level of alcohol during pregnancy is not determined.
      Prostaglandin-Induced Hair Growth

      research Prostaglandin-Induced Hair Growth

      162 citations , August 2002 in “Survey of Ophthalmology”
      This study found that latanoprost induces significant growth and pigmentation of lashes and ancillary hairs, with effects mirroring both brief and chronic treatments observed in patients and animal models.
      The Pharmacology of Methotrexate

      research The pharmacology of methotrexate

      155 citations , August 1991 in “Journal of The American Academy of Dermatology”
      This article reviews methotrexate's pharmacokinetics and toxicity, emphasizing the role of urinary excretion and leucovorin in avoiding most toxic reactions; it provides no new clinical results.
      Microneedles as the Technique of Drug Delivery Enhancement in Diverse Organs and Tissues

      research Microneedles as the technique of drug delivery enhancement in diverse organs and tissues

      140 citations , December 2017 in “Journal of Controlled Release”
      This study reviews the evolution and modifications of microneedle drug delivery systems, initially designed for percutaneous use, now expanded for targeting a variety of tissues and organs such as ocular, oral mucosal, and gastrointestinal, suggesting widespread future applicability.
      Hormesis And Medicine: Biphasic Dose-Response Relationship

      research Hormesis and medicine

      127 citations , June 2008 in “British Journal of Clinical Pharmacology”
      This study supports the conclusion that the hormetic dose-response model is the most prevalent and fundamental model in biological and biomedical sciences, applicable to a wide range of clinical conditions.
      Adult Polycystic Ovary Syndrome Begins in Childhood

      research Adult polycystic ovary syndrome begins in childhood

      124 citations , June 2002 in “Best Practice & Research Clinical Endocrinology & Metabolism”
      This article reviews polycystic ovary syndrome in adolescents, highlighting its endocrine and metabolic features, and reports no new clinical findings; the etiology may involve early-life abnormalities in androgen production.