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research An mTurq2-Col4a1 mouse model allows for live visualization of mammalian basement membrane development
This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.
research Development of an aequorin-based assay for the screening of corticotropin-releasing factor receptor antagonists
This study established a stable cell line for CRF1 receptor screening, which can be used to develop functional cosmetics and modulators potentially affecting hair re-growth.
research 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane
In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
research Tissue resident and follicular Treg cell differentiation is regulated by CRAC channels
This study found that deleting Stim1 and Stim2 in mature T regulatory cells disrupts Ca 2+ signaling, preventing their differentiation and leading to severe autoimmune disorders in mice.
research Systematic review – alopecia areata and tofacitinib in paediatric patients
This systematic review reports promising efficacy and safety of Tofacitinib for treating Alopecia Areata in children, though further randomized studies are needed due to the low quality of existing evidence.
research Proceedings of the International Conference on Translational and Integrative Medicine
This study evaluated the antimicrobial activity of a newly synthesized fluoroquinolone against Staphylococcus, Streptococcus, and Escherichia coli strains. The researchers compared results from the microdilution technique and agar disk diffusion method to EUCAST's recommended breakpoint values, building on promising in silico molecular docking tests.
research Developmental characteristics of cutaneous telocytes in late embryos of the silky fowl
In this study, researchers reported telocytes in the dermis of silky fowl embryos at different developmental stages, highlighting their immunophenotypes and interactions with other cells.
research Clinical profile of tinea capitis among rural children in Cuddalore district
In this study of 50 rural children with tinea capitis, 64% had the non-inflammatory type, while 28% had the inflammatory type, with most cases showing positive results in KOH examinations.
research Reliability and validity of the Turkish Alopecia Areata Quality of Life Index
This study successfully adapted the Alopecia Areata Quality of Life Index Questionnaire into Turkish, finding it to be valid and reliable for assessing the quality of life in Turkish patients with alopecia areata.
research Quaternary ammonium iminofullerenes improve root growth of oxidative-stress maize through ASA-GSH cycle modulating redox homeostasis of roots and ROS-mediated root-hair elongation
This study found that quaternary ammonium iminofullerenes (IFQA) can alleviate oxidative stress in maize caused by hydrogen peroxide, promoting root growth by enhancing antioxidant cycles and reducing ROS accumulation.
research Topical Delivery of Tofacitinib in Dermatology: The Promise of a Novel Therapeutic Class Using Biodegradable Dendritic Polyglycerol Sulfates
The researchers reported that dPGS-PCL as a carrier improved the penetration of tofacitinib in an ex-vivo human skin model compared to free tofacitinib, but did not show significant differences in inhibiting IL-6 and IL-8 during short incubation.
research TOFACITINIB IN OVERLAPPING AUTOIMMUNE AND AUTOINFLAMMATORY DISORDERS: A CASE REPORT OF A DUAL GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME AND HIDRADENITIS SUPPURATIVA
In this case report, a woman with Graham-Little-Piccardi-Lassueur Syndrome and hidradenitis suppurativa showed significant improvements in both conditions after six months of treatment with tofacitinib, a Janus Kinase inhibitor, with no recurrence or adverse events noted during a two-year follow-up.
research Quercetin-Based Advanced Delivery Systems – From Multimodal Nano-theranostics to Microneedles: a Recent Update on Their Preclinical Studies
This review explores quercetin's potential in multifunctional theranostic systems, highlighting its bioactivity and the challenges of improving its clinical application through innovative strategies like nanoencapsulation, while noting that research in this area is underdeveloped.
research TCM “medicine and food homology” in the management of post-COVID disorders
This review highlights the potential of TCM medicinal foods for managing post-COVID disorders and suggests they could provide a safe and efficient long-term therapy due to their milder nature.
research Chemical Fingerprint and Quantitative Analysis for the Quality Evaluation of Platycladi cacumen by Ultra-performance Liquid Chromatography Coupled with Hierarchical Cluster Analysis
This study established a rapid and accurate ultra-performance liquid chromatographic method for chemical fingerprinting and analyzing Platycladi cacumen, effectively distinguishing batches based on geographical and climatic conditions.
research Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter
This study found that the tetracycline-regulated transcription system effectively controls conditional gene expression in the mouse epidermis, allowing suppression and activation of specific genes with doxycycline.
research Systemic Tofacitinib in Alopecia Areata: A Single Center Retrospective Descriptive Cohort Study
This study found that tofacitinib was an effective and well-tolerated treatment for alopecia areata, with significant to moderate hair regrowth in 78% of patients observed.
research In Vivo and In Vitro Evaluation of PTeCA (1H‐Pyrrole‐2,3,4,5‐Tetracarboxylic Acid) in Hair Matrix as a Marker for Oxidative Cosmetic Treatment
This study observed that the degradation product PTeCA significantly increased in hair treated with oxidative cosmetics, suggesting it could be a reliable marker for detecting such treatments, with a proposed PTCA cut-off value using PTeCA as the gold standard.
research Treatment of androgenetic alopecia by exosomes secreted from hair papilla cells and the intervention effect of LTF
This study observed that in a mouse model of androgenetic alopecia, treatments with LTF, 5% minoxidil, and LTF-DPC-EXO significantly promoted hair regeneration compared to the model group, potentially through modulation of the PI3K/AKT signaling pathway.
research Genetic deletion of TNFα inhibits ultraviolet radiation-induced development of cutaneous squamous cell carcinomas in PKCε transgenic mice via inhibition of cell survival signals
In this study, researchers found that deleting TNFα in PKCε transgenic mice reduced the development of cutaneous squamous cell carcinomas induced by UV radiation or a chemical protocol.
research 801 TEC family kinase inhibitors as a novel class of therapeutics in alopecia areata
ITK inhibitors may effectively treat alopecia areata.
research Hair-Thread Tourniquet Syndrome; Emergent Diagnosable Condition
This article reviews cultural differences in the incidence of hair-thread tourniquet syndrome and finds it may be less prevalent in Iranian children compared to Europe, possibly due to social and cultural factors.
research A Patient Preference-Weighted Quantitative Benefit-Risk Analysis of Ritlecitinib for Alopecia Areata to Inform Medical Decision Making
research Quercetin and polycystic ovary syndrome
This review examines the potential therapeutic effects and mechanisms of quercetin for treating polycystic ovary syndrome, noting improved clinical parameters in some studies but presenting no new results.
research Best Practices for FACE-Q Aesthetics Research: A Systematic Review of Study Methodology
This study highlights ongoing limitations in the administration and reporting of FACE-Q Aesthetic scale data, recommending that future research follow the User's Guide for proper administration and scoring, justify the study's time frame, and provide sample size calculations for key outcomes.
research Tofacitinib for the Treatment of Three Immune-mediated Conditions in One Patient: Ulcerative Colitis, Pyoderma Gangrenosum, and Alopecia Areata
In this report, a female patient with ulcerative colitis, alopecia areata, and pyoderma gangrenosum showed improvement in all three conditions after being treated with tofacitinib.
research The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
This study found that quercitrin, a natural compound, enhances Wnt/β-catenin signaling and may help mitigate synapse loss and memory impairment in Alzheimer's models.
research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells
This study found that the combination of letrozole and quercetin loaded in spanlastics showed enhanced cytotoxicity and other anticancer effects against MCF-7 breast cancer cells compared to individual treatments.
research 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor
This study found that "early" transit amplifying cells, marked by CD271, are the first keratinocyte stem cell progenitors with distinct features, playing a significant role in early epidermal differentiation and regeneration.