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GlossaryPygeum africanum (Pygeum)

tree bark extract used for prostate health and hair growth

Pygeum africanum, also known as Prunus africana or African cherry, is a tree native to the montane regions of sub-Saharan Africa. Its bark is commonly used in traditional medicine and modern supplements to treat benign prostatic hyperplasia (BPH) and other urinary disorders. The extract is believed to have anti-inflammatory and antioxidant properties, which may also contribute to its use in promoting hair health and potentially addressing conditions like alopecia.

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Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentrations of Endogenous Anabolic Steroids: Relevance to Doping Analysis

research Influence of Saw Palmetto and Pygeum Africana Extracts on the Urinary Concentrations of Endogenous Anabolic Steroids: Relevance to Doping Analysis

2 citations, December 2020 in “Phytomedicine plus”

Taking Saw palmetto and Pygeum africana can change the levels of certain steroids in urine, which could cause confusion in doping tests.

Efficacy and Safety of a Dietary Supplement Containing a Lipid Co-Extract from Serenoa Repens and Pygeum Africanum for the Treatment of Androgenetic Alopecia in Women: Results of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

research Efficacy and Safety of a Dietary Supplement Containing a Lipid Co-Extract from Serenoa Repens and Pygeum Africanum for the Treatment of Androgenetic Alopecia in Women: Results of a Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2 citations, April 2016 in “Más dermatología”

The supplement with Serenoa repens and Pygeum africanum significantly increased active hair growth and decreased rest phase hair in post-menopausal women with hair loss, with only mild digestive side effects.

Oral Supplementation With L-Cystine, Serenoa Repens, Pumpkin Seed Oil, And Pygeum Africanum In Chronic Telogen Effluvium And Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

research Oral Supplementation With L-Cystine, Serenoa Repens, Pumpkin Seed Oil, And Pygeum Africanum In Chronic Telogen Effluvium And Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

September 2024 in “Journal of the American Academy of Dermatology”

The supplements improved hair density and reduced hair loss.

Oral Supplementation with L-Cystine, Serenoa Repens, Cucurbita Pepo, and Pygeum Africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

research Oral Supplementation with L-Cystine, Serenoa Repens, Cucurbita Pepo, and Pygeum Africanum in Chronic Telogen Effluvium and Androgenetic Alopecia: A Double-Blind, Placebo-Controlled, Randomized Clinical Study

July 2024 in “Skin Appendage Disorders”

The supplement significantly improves hair density and appearance in people with hair loss.

research Ethnopharmacological Review of Medicinal Plants for the Treatment of Alopecia

March 2023 in “International Journal of Advanced Research in Science, Communication and Technology”

Various medicinal plants like Polygonum multiflorum, Red ginseng extract, and Zizyphus jujuba can potentially treat hair loss, offering benefits like low cost and multiple ways of working. Other effective natural substances include Pygeum africanum, Seneroa, Urtica dioica, and more.

research What Do We Know About Phytotherapy of Benign Prostatic Hyperplasia?

67 citations, February 2015 in “Life Sciences”

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

research Herbs for Benign Prostatic Hyperplasia

54 citations, September 2002 in “Annals of Pharmacotherapy”

Herbal treatments can help with early-stage BPH symptoms, but more research is needed.

research Comparative Study of Two Dietary Supplements Inhibiting 5α-Reductase in Female Androgenetic Alopecia

May 2018 in “Más dermatología”

The higher dose supplement was more effective in treating female hair loss.

research Female Androgenetic Alopecia: New Pathophysiological Factors and Future Trends for a More Comprehensive Clinical Approach

September 2016 in “Más dermatología”

New factors in female hair loss include genetics, hormones, stress, and inflammation; future treatments should also focus on these areas and consider the patient's emotional well-being.

research Natural Compounds Used For Treating Hair Loss

February 2023 in “Current Pharmaceutical Design”

Natural remedies like certain plants can help reduce hair loss and promote hair growth.

research Pumpkin Seed Oil vs. Minoxidil 5% Topical Foam for the Treatment of Female Pattern Hair Loss: A Randomized Comparative Trial

4 citations, February 2021 in “Journal of Cosmetic Dermatology”

Pumpkin seed oil slightly outperforms minoxidil foam in treating hair loss with fewer side effects.

research Botanical Treatment for Polycystic Ovary Syndrome

January 2009 in “Elsevier eBooks”

Some plant-based treatments may help with ovary function, insulin resistance, and excess male hormones in PCOS, but more research is needed to confirm their safety and effectiveness.

Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

research Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition

124 citations, January 1993 in “The Prostate”

Finasteride effectively inhibits 5α reductase, while plant extracts like Permixon and Bazoton don't show significant results.

A Prospective, 1-Year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome

research A Prospective, 1-Year Trial Using Saw Palmetto Versus Finasteride in the Treatment of Category III Prostatitis/Chronic Pelvic Pain Syndrome

105 citations, January 2004 in “The Journal of Urology”

Finasteride improves chronic pelvic pain, saw palmetto doesn't.

research Pharmacological Therapy of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms: An Overview for the Practicing Clinician

98 citations, August 2004 in “BJU international”

Medications have become the main treatment for enlarged prostate symptoms, replacing surgery and watchful waiting.

Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

research Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

75 citations, November 2016 in “Medicines”

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations, May 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

research Hair Growth: Focus on Herbal Therapeutic Agents

41 citations, July 2015 in “Current Drug Discovery Technologies”

Some plants may help with hair growth and have fewer side effects than synthetic drugs, but more research is needed to confirm their effectiveness.

research Hair Loss and Herbs for Treatment

39 citations, September 2013 in “Journal of Cosmetic Dermatology”

Herbs can potentially treat hair loss by inhibiting a key enzyme and promoting hair growth, and deficiencies in zinc, biotin, and iron are linked to hair loss.

research Androgenetic Alopecia: Treatments and Efficacy

30 citations, January 2000 in “Dermatologic Clinics”

Finasteride and minoxidil are effective FDA-approved treatments for androgenetic alopecia.

research Novel Agents for the Treatment of Alopecia

29 citations, December 1998 in “Seminars in Cutaneous Medicine and Surgery”

New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.

research Hormone Therapy in Acne

24 citations, January 2013 in “Indian Journal of Dermatology, Venereology and Leprology”

Hormonal treatment is effective for women with acne not helped by usual treatments, especially if they have hormonal imbalances.

research Alopecia: Unapproved Treatments or Indications

22 citations, March 2000 in “Clinics in Dermatology”

Many treatments for hair loss lack proper testing and FDA approval, so their effectiveness is uncertain.

research A Preliminary Study on Topical Cetirizine in the Therapeutic Management of Androgenetic Alopecia

21 citations, June 2017 in “Journal of Dermatological Treatment”

Topical cetirizine improves hair density and thickness in androgenetic alopecia, but more research is needed.

research Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors

20 citations, March 2005 in “Current Medicinal Chemistry”

New compounds show promise for treating hair loss, enlarged prostate, and prostate cancer, with some being more effective and having different side effects than current treatments.