40 citations
,
July 2016 in “Pediatrics in review” This article reviews puberty's onset, development, and the factors affecting it, including nutrition, obesity, and gender dysphoria, and reports no new clinical results.
29 citations
,
February 2019 in “Environment international” This study found that higher prenatal and early childhood lead exposure may be associated with delayed pubertal development in girls, but not in boys, in Mexico City.
29 citations
,
February 2016 in “Scandinavian journal of urology” This study suggests a possible link between late puberty onset and decreased prostate cancer risk, while over-the-counter ibuprofen use was associated with increased risk.
22 citations
,
March 2019 in “Environmental health” This study observed that higher childhood fluoride exposure was associated with delayed pubertal development in Mexican boys aged 10-17, with no significant effects found in girls.
5 citations
,
May 2023 in “Science of the total environment” This study observed that higher PFAS concentrations during adolescence were linked to later pubertal development and lower estradiol levels in females, but not in males, potentially due to PFAS excretion with menstrual fluid.
5 citations
,
July 2019 in “Nutrients” This study found that boys in Mexico City with selenium intake below the recommended dietary allowance had lower odds of progressing to advanced stages of pubertal development, while no association was observed in girls.
2 citations
,
January 1988 in “Deep Blue (University of Michigan)” This study found that early adolescent girls who perceive themselves as undergoing pubertal changes report more intense and variable moods, with hormone activity and perceived pubertal status independently predicting mood fluctuations.
October 2025 in “Environment International” This study reports that prenatal and prepubertal exposure to organochlorine compounds and perfluoroalkyl substances may affect pubertal development at age 12, with observed changes in development patterns in both girls and boys, highlighting the need for further research.
37 citations
,
June 2011 in “Pediatrics in Review” This article reviews the physiological changes underlying normal pubertal milestones and emphasizes the importance of understanding these changes to assess pubertal abnormalities, without reporting new clinical findings.
29 citations
,
July 2011 in “Pediatrics in review” This article reviews various aspects of puberty, particularly focusing on the staging of sexual maturity and the factors influencing pubertal onset, but reports no new empirical results.
27 citations
,
October 2016 in “The Journal of Clinical Endocrinology and Metabolism” In this study, daughters of women with PCOS and control daughters showed no significant differences in metabolic and hormonal parameters, but more PCOS daughters exhibited hirsutism at advanced pubertal stages.
April 2025 in “International Journal For Multidisciplinary Research” This case report details the investigation and management of a 3-year-old girl with precocious pseudopuberty due to a Sertoli-Leydig cell tumor, highlighting the importance of early recognition and accurate diagnosis for effective treatment and prognosis.
6 citations
,
May 2021 in “JAMA network open” This study reported that higher weight-for-age z scores and rapid weight gain during infancy, especially from birth to 3 months, were linked to an increased likelihood of puberty onset in girls.
3 citations
,
June 2017 in “Deep Blue (University of Michigan)” This study found that prenatal exposure to fluoride and lead, as well as maternal micronutrient intake, may influence sexual maturation in adolescents in a sex-specific manner.
2 citations
,
April 2021 in “PLoS ONE” This study observed that girls in rural Bangladesh experienced pubertal milestones later than in some other populations, but progressed through puberty at a similar pace from breast development to menarche.
January 2026 in “Reproductive Toxicology” In this study, daughters of mothers who consumed 8 or more cups of coffee per day during pregnancy experienced pubertal development about 2 months earlier than daughters of mothers who did not consume coffee, whereas no such differences were observed among sons.
1 citations
,
November 2024 in “European Journal of Endocrinology” This study observed that higher childhood levels of DHEAS were associated with more advanced pubertal development and correlated with changes in DNA methylation near puberty-related genes in both boys and girls, potentially explaining the hormone's influence on puberty.
September 2002 in “Fertility and sterility” This study found that adolescent girls with PCOS experienced earlier thelarche and menarche compared to controls, and the authors suggest these patterns may relate to hyperandrogenism and increased body mass index.
36 citations
,
May 2017 in “The journal of sexual medicine” In this retrospective study, cyproterone acetate treatment in late-pubertal trans-girls was found to be generally safe and led to mild feminizing effects, with more rapid feminization occurring when combined with estrogens.
192 citations
,
January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
1 citations
,
May 2018 in “Clinical chemistry” This case report described a 9-year-old girl initially suspected to have complete androgen insensitivity syndrome, whose laboratory tests later suggested an alternative diagnosis involving atypical steroid metabolism patterns and hormonal responses.
284 citations
,
February 2008 in “Pediatrics” This review discusses the potential impact of endocrine-disrupting chemicals and body size on pubertal onset and progression, highlighting critical gaps and priorities for future research without presenting new clinical results.
53 citations
,
March 2010 in “British Journal of Dermatology” This study found that androgenetic alopecia is the leading cause of hair loss in adolescents and may indicate endocrine disorders, emphasizing the need for accurate diagnosis.
3 citations
,
July 2015 in “Pediatrics in review” This review discusses factors influencing the earlier onset of puberty, such as obesity and exposure to endocrine-disrupting chemicals, and emphasizes the need for further research and public health policy development.
January 2023 in “Endocrine Journal” This review discusses the challenges in optimizing glucocorticoid treatment for classic 21-hydroxylase deficiency, emphasizing individualized care and the need for comprehensive management, but presents no new findings.
January 2025 in “BMC Pediatrics” In this study conducted among healthy Iranian girls in Isfahan province, researchers found that the median onset age for menstruation was 12.05 years, breast development began at 9.89 years, and pubic hair development started at 10.14 years, with earlier puberty onset potentially indicating precocious puberty.
20 citations
,
May 1998 in “PEDIATRICS” This correspondence highlights a study on early pubertal development in young girls, noting that early pubic hair and breast development in African-American girls is likely due to increased androgen production, not estrogen or exogenous causes.
November 2007 in “Neuro-chirurgie/Neurochirurgie” This study reported that treatment with cyproterone acetate alone and then with incremental estrogen doses induced mild feminizing effects in late-pubertal trans-girls, with further feminization observed after adding estrogen.
July 2008 in “International journal of psychophysiology” This retrospective study found that cyproterone acetate, both alone and with estrogens, was safe, well tolerated, and induced modest feminizing effects in late-pubertal transgender female adolescents.
January 2016 in “Springer eBooks” Pubertal acne is linked to hormonal changes, affects quality of life, and is treated similarly to adult acne.