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The document concludes that pediatricians play a vital role in supporting adolescents through puberty and should enhance their competence in this area.

This study found that transdermal DHT treatment increased penile length in boys with 5α-reductase type 2 deficiency, but post-pubertal growth was limited and carried potential prostate complications.

This study found that prepubertal girls have significantly higher levels of estrogens and androgen metabolites compared to age-matched boys, which may contribute to their earlier onset of puberty.

This case report from a pediatric setting highlighted how an 11-year-old with Hashimoto thyroiditis experienced atypical manifestations such as short stature, pubertal issues, and hair loss after starting levothyroxine therapy, underscoring the need for early diagnosis and multidisciplinary care to improve health outcomes.

In this case report, an 11-year-old girl with hypothyroidism was found to have Hashimoto thyroiditis after presenting with hair loss, short stature, and pubertal disturbances; the study emphasizes the importance of early diagnosis and personalized thyroid hormone therapy for better outcomes.

This case study reports that hormonal imbalances in a young boy with precocious pseudopuberty returned to normal after the removal of a testicular interstitial cell tumor, with normal spontaneous puberty following.

This study found that older age at puberty may be associated with lower semen quality and altered reproductive hormone levels in young men, though only some results were statistically significant.

In this study, reduced androgen receptor gene methylation and shorter CAG repeats in children with premature pubarche may lead to increased hair follicle sensitivity to steroid hormones, potentially causing early pubic hair development.

This case report describes a 24-month-old girl from Nigeria with idiopathic precocious puberty, emphasizing the financial barriers to necessary treatment in developing countries.

This study suggests that combining testosterone and letrozole may accelerate puberty in boys with constitutional delay by increasing serum androgen bioactivity and facilitating pubertal progression.

This article discusses diagnostic evaluations and management strategies for isosexual precocious puberty, emphasizing the importance of accurate identification and appropriate treatment, but it provides no new clinical findings.

This article reviews the normal and delayed maturation of the HPG axis and pubertal development in boys and girls, emphasizing clinical aspects of diagnosing and managing delayed puberty, but it reports no new clinical findings.

This study found that serum DHEA levels increase earlier and are higher in girls compared to boys through various stages of puberty, reflecting their earlier pubertal development.

This case study reports that in an 8-year-old male, a pituitary adenoma causing isolated high LH secretion led to early testosterone-driven puberty without typical testicular enlargement, highlighting the differential roles of LH and FSH in pubertal development.

This study identified multiple environmental, dietary, and familial risk factors associated with precocious puberty in girls, such as exposure to cosmetics, frequent consumption of snacks, and mother's early pubertal development.

This case report emphasizes the importance of early diagnosis of Swyer Syndrome in adolescents with slow pubertal progression and primary amenorrhea due to the high risk of germ cell cancers.

This study found that developmental changes in testosterone synthesis and gene regulation may explain age differences in corticosterone release in response to stress between adolescent and adult rats.

This study found that acne prevalence in late pubertal boys was 85%, compared to 15% in girls, with higher DHT levels noted in acne-affected adolescents compared to those without.

This study found that cyproterone acetate treatment in late-pubertal trans-girls was safe, well-tolerated, and induced mild feminizing changes, with more pronounced effects when combined with estrogens.

This study observed that serum levels of oestradiol, testosterone, and androstenedione increase rapidly with the onset of puberty and continue to rise after menarche, with anovulatory cycles being common in early postmenarchal girls.

This case study reports successful treatment of a 19-year-old with Satoyoshi syndrome using a combination of carbamazepine, methotrexate, prednisolone, and sex-steroids, improving muscle spasms, alopecia, and quality of life.

In this case report, an 18-year-old Vietnamese female with primary amenorrhea and normal female phenotype was most likely diagnosed with müllerian agenesis, highlighting its association with embryologic underdevelopment of the müllerian duct.

This article reviews various causes and diagnostic approaches to delayed puberty in boys and girls and does not report any new clinical findings; it emphasizes the importance of distinguishing between different underlying conditions.

In this cohort study of young Danish men, self-reported older age at voice break was linked to certain reproductive hormone changes that suggest reduced male fecundity, but associations with semen characteristics and testicular volume were not statistically significant.

Finasteride affects male rat genitalia development, causing abnormalities during specific pregnancy days.

This study used a mouse model to reveal that S100A4-positive cells, specifically fibroblasts and immune cells, play a crucial role in nipple development, essential for successful lactation, despite no issues with mammary morphology or milk production.

This review explores the hypothesis that polycystic ovary syndrome may originate in fetal life due to genetic predispositions and environmental influences, but it reports no new clinical findings.

This review integrates studies on mouse models and human clinical observations to highlight the role of immune cells in skin development and how their dysregulation leads to skin disorders, suggesting potential therapeutic pathways for skin regeneration.

This case report describes a 13-year-old with DSD raised as female, exhibiting hoarseness and clitoral enlargement, with hormonal assessments not indicating common related deficiencies.

Different types of long-lasting stem cells are responsible for the growth and upkeep of the mammary gland.