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Finasteride doesn't improve survival in LNCaP tumor model during off-cycle of therapy.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Saw palmetto supplements may reduce prostate cancer cell growth without being toxic.

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

Finasteride may affect PNMT, causing side effects.

Cernitin™, a pollen extract, was found to significantly reduce pain and inflammation in rats with chronic prostatitis, suggesting it could be a useful alternative to certain anti-inflammatory drugs.

Human prostate cells produce more WISP1/CCN4 when there's not enough oxygen.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

Testosterone therapy improves physical function, strength, and body composition in older men with low testosterone levels.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Fat cells help recruit healing cells and build skin structure during wound healing.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Guidelines for diagnosing common hair loss include detailed history, clinical examination, and various diagnostic techniques.

Finasteride effectively treats baldness but may cause sexual side effects.

Testosterone's muscle-building effects do not require its conversion to DHT.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

The document concludes that accurate diagnosis and personalized treatment are important for skin problems in women with PCOS.

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

The circadian clock influences the behavior and regeneration of stem cells in the body.

Minoxidil and finasteride are effective for male hair loss, minoxidil for female hair loss, and various treatments like corticosteroids work for alopecia areata; treatment should be tailored to the individual.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

The transscrotal testosterone patch normalizes hormone levels in men with AIDS and weight loss but does not improve weight, body mass, or quality of life.

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.