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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

AGA affects many, progresses differently, and early treatment is crucial.

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Prostate cancer patients need early psychological and sexual support during radiotherapy to improve their quality of life.

Long-term high testosterone levels can improve bone density and reduce body fat but may increase the risk of prostate cancer and high blood pressure.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

Increased free testosterone can lead to stronger bones and less body fat but also higher risks of prostate cancer, hair loss, spine issues, and high blood pressure.

The document concludes that understanding health requires considering evolutionary perspectives on reproductive fitness, and recognizing the complexity of factors like diet, testosterone, and sexual orientation.

Testosterone replacement therapy improves libido, mood, muscle strength, and bone density in men with Testosterone Deficiency Syndrome.

Using oral minoxidil and dutasteride together can quickly increase hair growth and volume with minimal side effects.

Finasteride's link to health issues like male breast cancer, infertility, and prostate cancer needs more research through placebo-controlled trials to confirm.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

New steroid compounds effectively inhibit 5α-reductase and may treat hair loss.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

5α-Reductase inhibitors can negatively affect male sexual function and, in some cases, significantly reduce sperm count, but these effects may be reversible.

Hair loss drugs may cause sexual issues and infertility in men.

Dutasteride and finasteride affect different cell types differently.

Men taking 5-alpha reductase inhibitors for prostate issues may be less likely to experience severe COVID-19, but it doesn't prevent ICU admission or death.

Medications for hair loss and prostate issues can significantly increase the risk of sexual side effects and other negative symptoms.

Some men experience persistent sexual, neurological, and psychological symptoms after stopping finasteride, but evidence of permanent damage is inconclusive.

Finasteride for hair loss may increase the risk of certain cancers and has side effects; better regulation and education on its use are needed.

Sorafenib helps some advanced cancers alone or with other treatments, but not all, and research continues to improve its use.

Finasteride before TURP reduces blood loss and slightly improves early postoperative quality of life.

Pumpkin seed products may help improve prostate and bladder health by blocking certain enzymes and hormone receptors.

Finasteride and dutasteride are effective for male hair loss and enlarged prostate but may cause reversible sexual side effects.

TURP specimens should be checked for various tumors, not just common prostate issues.

Tamsulosin may slightly increase dementia risk compared to other treatments for enlarged prostate.

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.