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Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

The document does not determine if adults with aphallia are fertile.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Transgender females can reach their target estrogen levels using estradiol patches, especially if oral treatments fail or if they're at risk for blood clots. Often, the highest dose patch is needed.

Sons of mothers with polycystic ovary syndrome (PCOS) have a higher risk of obesity and insulin resistance, possibly due to certain genes and factors passed down from their mothers.

The document reports three sisters with Woodhouse-Sakati syndrome showing typical symptoms and unusual gynecological anomalies.

Understanding how DHT works is important for diagnosing and treating hormone-related disorders.

Polycystic Ovary Syndrome can cause hair loss and skin issues, and early treatment is important for preventing complications.

Hormonal imbalances are a key cause of missed menstrual periods in women.

Testosterone is important for male development and health, and careful replacement can treat low levels.

Treatment restored normal sexual characteristics and blood condition in a patient with testicular cancer.

A 15-year-old girl with no menstrual period was diagnosed with a genetic condition that makes her body unable to respond to male hormones, leading to female characteristics despite having male genetic makeup.

Amenorrhea is when a woman doesn't have periods, with primary amenorrhea starting by age 15 or within five years of breast development, and secondary amenorrhea when periods stop for three months. It affects 3-4% of women not pregnant, breastfeeding, or in menopause, mainly due to polycystic ovary syndrome, hypothalamic amenorrhea, hyperprolactinemia, and ovarian failure.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

Testosterone therapy helps boys with hormone deficiencies develop normal male characteristics and grow properly.

Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Amenorrhea, or the absence of periods, should be evaluated by age 15 or within five years of early breast development, and is most commonly caused by conditions like polycystic ovary syndrome and hypothalamic amenorrhea.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Estrogens are key for bone growth spurts in both boys and girls and affect growth into adulthood.

Puberty involves complex hormonal changes, varies by gender and ethnicity, and requires careful monitoring for abnormalities.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

The testes produce important hormones like testosterone and others that play key roles in male body functions.

The 18-year-old girl likely has a condition called müllerian agenesis, which caused her to not have a uterus and experience no menstrual periods.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.