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The document is a detailed guide on skin conditions and treatments for dermatologists.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

Thyroid hormone may be useful for treating various skin conditions and needs more research.

Some parents have a mild form of congenital adrenal hyperplasia without symptoms, and they usually don't need treatment.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

The document concludes that treating androgen excess needs patience, managing expectations is important, and many drugs used are not officially approved, suggesting cosmetic options for mild cases.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

The document is a detailed medical reference on skin and genetic disorders.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The document concludes that various dermatological treatments and drugs can cause skin reactions and side effects.

Damaging mutations in NFKB2 cause a severe and distinct form of primary immunodeficiency with early-onset and often ACTH-deficiency.

Thalidomide works best for skin lupus not helped by antimalarials, but has many side effects; other treatments are less effective, especially if patients also have systemic lupus.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Hair loss in systemic lupus erythematosus patients is unique and improves with treatment.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Herbal remedies can cause adverse effects and need more safety research.

Dexamethasone speeds up hair loss in mice, while cyclosporin A slows it down.

Finasteride may help treat chronic CSC, improving vision.

Metformin and rosiglitazone improve blood vessel function in women with PCOS, with metformin also reducing insulin resistance and testosterone levels.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

Siblings with signs of virilization should be tested for non-classical congenital adrenal hyperplasia, which does not affect adult height but may impact fertility and well-being if untreated.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

High glucocorticoids cause pancreatic malfunction and malabsorption, reversible with enzyme supplements.