Search
for
Sort by
Research
120-150 / 1000+ resultsresearch The sheep KAP8-2 gene, a new KAP8 family member that is absent in humans
This study found that sheep possess a polymorphic KAP8-2 gene that shares high sequence identity with the KAP8-2 gene in goats and reindeer.
research CLED: A Calcium-Linked Protein Associated with Early Epithelial Differentiation
research Characterization of Bsk mice: I. The Bsk mutation does not involve a recombination of cornea-specific keratin 12 and skin-specific hair keratin genes.
This study found that the Bsk phenotype in mice did not result from a recombination event between specific keratin genes, leaving the gene linked to this mutation unidentified.
research Efficacy and Safety of Long-Pulsed 755-nm Alexandrite Laser for Keratosis Pilaris: A Split-Body Randomized Clinical Trial
In this study, long-pulsed 755-nm alexandrite laser treatment for keratosis pilaris significantly improved skin roughness and redness, as well as follicular plug reduction, with good safety and patient satisfaction compared to a moisturizing lotion alone.
research A newborn presenting with congenital blistering
This report describes a case of epidermolytic hyperkeratosis in a newborn and her mother, both possessing a specific KRT1 gene mutation known to cause this skin disorder.
research CKD Nonprogressors:A Commonly Underrecognized Syndrome?
This study found that in a large cohort of chronic kidney disease patients, nonprogression or regression of the disease was more common than progression or kidney failure, especially with advancing age.
research Enhancement of Human Hair Growth UsingEcklonia cavaPolyphenols
This study found that Ecklonia cava polyphenols increased human dermal papilla cell proliferation and extended hair shaft length in vitro and ex vivo, suggesting potential as a therapeutic candidate for hair loss.
research Keratosis pilaris
This article provides an overview of keratosis pilaris, discussing its different variants, possible pathogenesis, and treatment options, without reporting new clinical results.
research Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis
This study found that activating CXCR2 on ras-transformed keratinocytes promotes migration and tumor development in a mouse skin model.
research Human KAP Genes, Only the Half of it? Extensive Size Polymorphisms in Hair Keratin-Associated Protein Genes
This article reviews extensive genetic polymorphisms in the keratin-associated proteins of human hair, indicating complexity but reporting no new clinical results and calls for further research on their potential impact on hair structure.
research CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways
In this study, researchers developed two novel mouse models to investigate how CD271 deletion in keratinocytes affects skin homeostasis, finding that it leads to changes resembling dysplastic skin conditions with immune cell recruitment and inflammatory cytokine release.
research Poster presentationsSG11 KRT14 pathogenic or likely pathogenic variants beyond epidermolysis bullosa: dermatopathia pigmentosa reticularis
This article presents a family case study of dermatopathia pigmentosa reticularis linked to a specific KRT14 gene variant, detailing symptoms and stressing the importance of molecular diagnosis for management.
research Expression of novel keratin associated protein 5 genes in the cuticle layer of human hair follicles
This study identified the expression sites of five KAP5 genes on human chromosome 11q13.5 in scalp skin sections but did not explore their detailed distribution within hair follicles.
research Review: Evolution and diversification of corneous beta‐proteins, the characteristic epidermal proteins of reptiles and birds
This review provides an overview of the molecular evolution of corneous beta-proteins in reptiles and birds, highlighting their distinct genetic origin and role in epidermal structures, but reports no new results.
research 269 Down-regulatory role of cholecystokinin on psoriatic epidermal inflammation
This study found that sulfated CCK octapeptide reduces psoriasis-like skin inflammation in mice, suggesting a new pathophysiological role for CCK in regulating epidermal inflammation.
research An epistatic effect of KRT25 on SP6 is involved in curly coat in horses
In this study, genetic variants in the KRT25 and SP6 genes were found to be responsible for curly hair in horses, with the KRT25 variant also causing hypotrichosis due to an epistatic effect.
research Pmg-1 and Pmg-2 constitute a novel family of KAP genes differentially expressed during skin and mammary gland development
This study identified two novel genes, pmg-1 and pmg-2, expressed in various skin and gland tissues and potentially involved in the differentiation of epithelial cells in epidermal appendages.
research Identification and sequence analysis of the keratin-associated protein 24‐1 (KAP24-1) gene homologue in sheep
In this study, researchers identified a putative ovine KAP24-1 gene in sheep, revealing four unique DNA sequences with some similarity to KRTAP24-1 sequences from other species.
research Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation
This study found that inhibiting PKC-β activity with bisindolylmaleimide reduces pigmentation in the skin and hair of guinea pigs and mice by preventing tyrosinase activation.
research Activation of platelet-rich plasma by pulse electric fields: Voltage, pulse width and calcium concentration can be used to control and tune the release of growth factors, serotonin and hemoglobin
The authors concluded that controlling voltage, pulse width, and calcium concentration in pulse electric field-activated platelet-rich plasma enhances the release of growth factors and serotonin without causing clot formation, suggesting potential clinical advantages over bovine thrombin-activated PRP.
research 565 Cutaneous delivery of LEKTI via an engineered strain of staphylococcus epidermidis for the treatment of netherton syndrome
ATR12-351 ointment safely delivers LEKTI protein to the skin, reducing enzyme activity in Netherton syndrome.
research Wool Keratin-Associated Protein Genes in Sheep—A Review
This review explains the genetic diversity of sheep wool keratin-associated protein genes and explores how this variation might be leveraged for selective breeding to enhance wool fiber traits.
research Location of keratin-associated proteins in developing fiber cuticle cells using immunoelectron microscopy
This study found that keratin-associated proteins form part of the developing exocuticle and a-layer in hair fiber cuticle cells, while cornified envelope proteins were absent.
research Novel mutations in the keratin-74 (KRT74) gene underlie autosomal dominant woolly hair/hypotrichosis in Pakistani families
research Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis
This review discusses the physiological roles of the epidermal differentiation complex and its potential involvement in psoriasis, but it reports no new experimental findings.
research The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting
This review discusses recent research on the Dickkopf protein family's involvement in non-cancerous diseases and considers their potential as biomarkers and therapeutic targets without presenting new experimental results.
research Variation in the Exon 3–4 Region of Ovine KRT85 and Its Effect on Wool Traits
This study suggests that variations in α-keratin proteins influence the structure and characteristics of wool fibers, indicating that keratin genes could serve as useful markers for identifying different wool traits.
research Molecular Evolution and Protein Structure Variation of Dkk Family
This study analyzed the molecular evolution and functional divergence of the Dkk gene family, finding accelerated evolution in Aves and Reptilia and identifying functional differences that may impact hair follicle development via Wnt signaling inhibition.
research Multiple Roles of Integrin-Linked Kinase in Epidermal Development, Maturation and Pigmentation Revealed by Molecular Profiling
This study found that integrin-linked kinase is crucial for various epidermal functions, including differentiation and barrier formation, and also plays a previously unreported role in melanocyte development and function.