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Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

Apremilast was not effective in treating moderate-to-severe alopecia areata.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

No systemic treatment for alopecia areata has strong evidence of effectiveness.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Drug repurposing is a cost-effective way to find new uses for existing drugs, speeding up treatment development.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

Some people experience severe, long-lasting side effects from fluoroquinolone antibiotics, leading to the recommendation of limited use and increased awareness of these risks.

Some patients with mycosis fungoides or Sézary syndrome experience hair loss, which may be similar to alopecia areata or linked to skin lesions, possibly due to abnormal T cells, and bexarotene can help treat it.

Injection lipolysis effectively reduces small fat deposits and should be done with care and proper patient selection.

The document concludes that treatment for cutaneous T-cell lymphoma should be customized to each patient's disease stage, balancing benefits and side effects, with no cure but many patients living long lives.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

Skin problems like acne, dry skin, and nail and hair changes are common in patients taking EGFR inhibitors.

Levetiracetam is widely used and generally well-tolerated for treating idiopathic generalized epilepsies, with tiredness as the main side effect.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

New treatments for a chronic skin condition show promise, but individualized plans are crucial due to varying responses.

Mice with enhanced regeneration abilities may help develop new regenerative medicine therapies.

Prostaglandin E2 affects human platelet activity in complex ways that could lead to personalized heart disease treatments.

Aromatase inhibitor therapy for breast cancer increases the risk of hair loss and thinning.

Dutasteride safely promotes hair growth and reduces hair loss, with mild side effects.

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

Different hair growth problems are caused by genetic issues or changes in hair growth cycles, and new treatments are being developed.

Steroidogenic isoenzymes may help improve treatments for common hair loss.

Young women with PCOS have a higher risk of high blood pressure and metabolic syndrome, but these risks may decrease after age 40.

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

New treatments targeting immune pathways show promise for severe hair loss but need more research for safety and effectiveness.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

The document provides advice on how to recognize and treat skin-related side effects of cancer drugs known as EGFR inhibitors.