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The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

Androgens cause skin issues like acne and hair growth in women, often due to PCOS, and can be treated with medication and lifestyle changes.

Skin problems are very common in people with end-stage kidney disease.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Sexual activity can spread T. interdigitale, needing quick antifungal treatment to avoid permanent scarring.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Graft-versus-host disease is a complication where donor immune cells attack the recipient's body, often affecting the skin, liver, and gastrointestinal tract.

5α-reductase inhibitors increase the risk of sexual dysfunction, especially in men with enlarged prostate.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Finasteride can reduce fertility in some men, but stopping it increases sperm count.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.

Women with polycystic ovary syndrome tend to have a longer distance between the clitoris and anus.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.

Smoking harms skin health, causing slower wound healing, more wrinkles, and worsening some skin conditions, but may protect against certain others.

Group a wide range of chemicals, not just phthalates, for assessing risks to male reproductive health.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

ALA-PDT is effective and safe for chronic X-ray dermatitis, providing complete or partial remission.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.