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This study found that four new progesterone derivatives reduced prostate weight in gonadectomized hamsters, suggesting potent in vivo antiandrogenic effects similar to finasteride.

In a study using a mouse model, HF-MSCs were reported to enhance ovarian function in cyclophosphamide-induced premature ovarian failure more effectively than HU-MSCs, potentially by preventing ferroptosis in granulosa cells via the KEAP1/NRF2/HO-1 pathway.

This single-patient case study reported promising results for severe, corticosteroid-resistant alopecia areata, with treatment using exosomes derived from mesenchymal stromal cells leading to almost complete hair regrowth in 12 weeks and favorable changes in inflammatory markers, suggesting potential for further investigation.

This case report suggests that ovarian steroid cell tumors should be considered in postmenopausal women with hirsutism and elevated testosterone, with surgery being effective in resolving symptoms and preventing recurrence.

This study reviewed various dermatological conditions associated with oral contraceptive use, highlighting increased pigmentation, decreased sebum production, and changes in hair growth, among other effects.

This review discusses potential treatments for androgen excess in polycystic ovary syndrome and reports no new findings, emphasizing the importance of individualized antiandrogenic management to minimize side effects.

This case report describes a rare instance of Satoyoshi syndrome in a 27-year-old Asian American woman, notable for her normal ovarian function despite typical syndrome features.

This study concluded that a regimen of transdermal estradiol and oral medroxyprogesterone acetate effectively reduces hirsutism while minimizing side effects in women with polycystic ovary syndrome.

This case series detailed three postmenopausal women with ovarian steroid cell tumors, highlighting that such tumors may present asymptomatically or with virilization, and found surgery effectively normalized androgen levels, with distinctive imaging features aiding diagnosis.

This study reported that structure-guided engineering of CYP154C2 mutants significantly improved the 2α-hydroxylation of androstenedione and testosterone, with enhanced conversion efficiency and substrate selectivity compared to the wild-type enzyme.

Certain enzymes react strongly with some hormones in rat skin during hair growth, mainly in sebaceous glands and hair sheaths.

This study found that the steroidal aromatase inhibitor exemestane stimulated proliferation of human osteoblast cells, suggesting both androgen receptor-dependent and independent pathways are involved.

This study found that exposure to sex steroid biosynthesis inhibitors increases the expression of piRNA pathway genes in frog larvae, suggesting these genes play a role in gonadal sex differentiation.

Women's ovarian hormones and adrenal androgens change throughout life, affecting hair loss and health.

GABAergic steroid precursors reduce ethanol withdrawal symptoms in certain mice.

Treating ovarian-related inflammation may help hair regrowth in women with alopecia areata.

This case report describes a woman with hyperandrogenism and menstrual disturbances, where an ovarian steroid cell tumor was identified and removed, leading to resolution of symptoms.

Anti-androgens are not better than birth control pills for PCOS, but can help with excess hair if pills don't work.

In this study, introducing the rat OTC gene into spf-ash mice led to increased OTC activity and normalized hair growth and biochemical markers like urinary orotic acid and serum citrulline, partially correcting the symptoms of OTC deficiency.

Clofazimine may be effective for treating ashy dermatosis.

This study found that women with polycystic ovary syndrome have more pronounced metabolic alterations and higher androgen levels compared to women with eumenorrheic hyperandrogenism, suggesting EuHyperA may be a milder form of PCOS.

This study found that androgenic steroids, particularly androstenedione and androstanedione, significantly reduced the growth of certain dermatophytes, suggesting hormonal influence on fungal infections in hair follicles.

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

This study identified three subgroups of women with PCOS with distinct androgen profiles, finding that the subgroup with adrenal-derived androgen excess had the highest insulin resistance and rates of hirsutism and hair loss.

This report describes two cases of alopecia in neutered female ferrets linked to neoplastic tissue at the site of an ovarian pedicle, suggesting an ovarian origin for the tumors.

This study synthesized new heterocyclic steroid derivatives and reported their promising antiproliferative activity against breast and prostate cancer cell lines, highlighting selectivity and impact on signaling pathways even in cells resistant to certain treatments.

This case report highlights a Palestinian woman with a rare ovarian steroid cell tumor, underscoring the diagnostic challenges and potential for disease progression despite treatment attempts with various chemotherapy regimens.

This research investigated the design and synthesis of steroid-based compounds as aromatase inhibitors for breast cancer, finding that certain structural modifications significantly enhance their inhibitory potency.