Alopecia Attributed to Neoplastic Ovarian Tissue in Two Ferrets

    April 2003 in “ PubMed ”
    Mary M. Patterson, Arlin B. Rogers, Mark D. Schrenzel, Robert P. Marini, James G. Fox
    TLDR Hair loss in two ferrets was caused by ovarian tissue tumors, not adrenal issues.
    The document reported two cases of alopecia in neutered female ferrets linked to neoplastic tissue at the ovarian pedicle, rather than the more common adrenal gland dysfunction. Both ferrets exhibited high levels of androstenedione and 17-hydroxyprogesterone, but not estradiol. Surgical removal of the abnormal tissue in one ferret led to a rapid decrease in hormone levels and hair regrowth. Histological analysis showed features of sex cord-stromal tumors, suggesting an ovarian origin due to their location, as accessory adrenal tissue is typically found near adrenal glands or in cranial perirenal fat. Immunohistochemical analysis did not conclusively identify the source of the steroidogenic cells.
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