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This review discusses the potential of stem cell-based therapies combined with artificial nerve grafts for improving recovery in animal models of severe peripheral nerve injury, highlighting the need for further research on their application to humans.

This review summarizes a 15-year collaboration on the role of synaptic-like vesicles in mechanosensory nerve terminals and suggests potential therapeutic implications for conditions like hypertension and muscle spasticity.

This study found that using induced pluripotent stem cell-derived mesenchymal stem cells with acellular nerve allografts significantly improved axon regeneration and functional recovery in rats with sciatic nerve injuries, suggesting a promising approach for clinical nerve repair therapies.

This study proposes that the terminal tuft structure in sensory nerve endings, involving Schwann cell processes and axon fingers, potentially plays a role in mechano-electric transduction in rats.

Smart microneedles improve hair loss treatment by delivering drugs precisely with fewer side effects.

This study found that overexpression of neurotrophin 4 in mouse skin increased hair follicle and Meissner corpuscle innervation without altering sensory neuron numbers, differing from brain-derived neurotrophic factor by not affecting Merkel cell numbers.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

This review discusses triboelectric nanogenerator (TENG) devices for body-integrated electrical stimulation therapy and suggests they may revolutionize personalized healthcare, but it reports no new clinical results.

In this study, researchers developed a programmable system using engineered nanovesicles from hair follicle stem cells to modulate immune responses, which showed promise in precisely controlling inflammation, promoting immune balance, and accelerating wound healing, particularly for infected wounds.

This narrative review from the authors discusses mechanical scalp stimulation as a potential treatment for androgenetic alopecia, suggesting it has a biologically plausible mechanism but immature clinical evidence; marketing of these devices currently outpaces their supporting data, indicating a need for better-controlled trials.

This study found that transplanting human hair follicle pluripotent stem cells can promote the recovery of sciatic nerve function in a mouse model of nerve impingement.

This review highlights recent advancements in microneedle technology, noting its ability to enhance transdermal drug delivery, biosensing, cancer treatment, and skin disease repair, while emphasizing its potential for improving patient compliance and reducing side effects.

This study found that the opioid system, particularly via the delta opioid receptor, broadly regulates cutaneous mechanosensation, including touch, and suggests targeting this receptor could alleviate injury-induced mechanical hypersensitivity.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This review discusses recent advancements in microneedle technology for hair loss treatment, highlighting their ability to enhance drug delivery and improve hair follicle survival in transplantation, while also exploring their potential integration with tissue engineering to address regeneration challenges.

In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.

This study found that using the OptoTrkA system to control TrkA activity with blue light enhanced proliferation, migration, and differentiation of hair-follicle-derived stem cells into neuronal and glial cells.

Deep Brain Stimulation helps manage Parkinson's symptoms when medication isn't enough.

In a mouse model of deep skin burns, this study found that a neuro-inspired biomimetic microreactor, when delivered through a hydrogel and activated by near-infrared light, significantly promoted functional skin regeneration, sensory recovery, and hair follicle formation.

This study suggests that nestin-expressing hair follicle stem cells, when transplanted into transgenic mice with sciatic nerve injury, can differentiate into motor neurons and reduce muscle atrophy.

This study reported successful outcomes in over 40 patients undergoing reparative surgical techniques for previously unsuccessful hair restoration, with significant improvements in appearance despite potential challenges like limited donor hair and scalp scarring.

This review discusses neuroimmune communication in skin disorders and peripheral neuropathic pain, highlighting the complex interactions between sensory neurons and immune cells; it reports no new clinical results but suggests potential future therapies.

This review categorizes current research on neural organogenesis and highlights potential future applications for treating central nervous system diseases, but reports no new clinical results.

This article briefly describes local anesthesia techniques for hair restoration surgery that aim to enhance patient comfort but reports no new research results.

This narrative review suggests that while mechanical scalp stimulation has a plausible mechanism for aiding androgenetic alopecia, its clinical evidence is insufficient, and the marketing of stimulation devices currently outpaces their efficacy data.

This study found that late embryonic skin injuries can regenerate multiple tissue types, but this ability is hindered postnatally due to fibroblast-driven hyperinnervation, which can be mitigated to enable regeneration.

This source reviewed contemporary methods of local anesthesia for hair transplantation, highlighting current innovations and identifying key areas for improvement and the integration of various techniques within practical trichology and plastic surgery.

This review discusses the state-of-the-art in photobiomodulation therapy for oral and dental applications and emphasizes the need for education, training, and addressing logistical issues for its routine use.

This review discusses recent advances in microneedle technology for androgenetic alopecia treatment, focusing on improved follicular delivery and various therapeutic mechanisms, while highlighting challenges in translating preclinical findings to clinical use.

This study found that Botox® was most effective at a 25 U/ml concentration, while Dysport® and Neurobloc® were optimal at 100 U/ml for producing anhidrotic areas after injections.