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Oxidative stress plays a significant role in vitiligo, and both skin and non-skin cells may be involved.

The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

The document concludes that non-binary individuals need compassionate support and recognition in healthcare, without being pathologized.

Hair growth phase and certain genes can speed up wound healing, while an inflammatory mediator can slow down new hair growth after a wound. Understanding these factors can improve tissue regeneration during wound healing.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.

Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.

The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.

Visible light can damage skin and most sunscreens don't block it well; more research is needed on its effects and protection methods.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

Tight junctions are key for skin protection and controlling what gets absorbed or passes through the skin.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.

Treating psoriasis on the scalp, nails, and skin folds is challenging, often requiring systemic treatments for severe cases, with some success in topical and biologic treatments.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Skin has specialized touch receptors that can tell different sensations apart.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Advanced human skin models improve drug development and could replace animal testing.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Stress can worsen skin conditions by affecting hormone levels and immune response.