91 citations
,
August 2015 in “Anais Brasileiros De Dermatologia” This review discusses the clinical, epidemiological, and pathophysiological aspects of female pattern hair loss, reporting no new research findings.
66 citations
,
June 2018 in “International Journal of Women's Dermatology” This article discusses treatments for female pattern hair loss, highlighting that oral antiandrogens and topical minoxidil can effectively arrest progression and reverse miniaturization in many patients with mild-to-moderate cases, but it reports no new clinical results.
64 citations
,
August 2014 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study found that biallelic mutations in the TTC7A gene affect lymphocyte and gut epithelial cell function, thereby contributing to the development of inflammatory bowel disease in patients.
60 citations
,
July 2020 in “ACS Nano” This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.
57 citations
,
October 2013 in “international journal of endocrinology and metabolism” This review discusses clinical features, differential diagnosis, and treatments for female pattern hair loss, emphasizing the use of 2% topical Minoxidil and exploring alternative off-label therapies.
51 citations
,
May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology” This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.
49 citations
,
May 2013 in “JAMA Dermatology” This study found that moderate to severe androgenetic alopecia is an independent predictor of increased mortality risk from diabetes mellitus and heart disease in both sexes.
48 citations
,
October 2014 in “International Journal of Cardiology” This meta-analysis found that people with alopecia have an increased risk of coronary heart disease and several cardiovascular risk factors compared to those without alopecia.
43 citations
,
November 2019 in “American Journal of Clinical Dermatology” This review discusses female androgenetic alopecia, highlighting its diagnostic challenges and management strategies, but it reports no new results.
43 citations
,
April 2017 in “Experimental Dermatology” This review summarizes the genetic studies on female pattern hair loss, highlighting the lack of clearly identified susceptibility loci and suggesting distinct aetiological differences from male pattern hair loss.
42 citations
,
January 2011 in “European Journal of Dermatology” In this study, higher scores of HOMA-IR and FIRI suggested that male patients with early-onset androgenetic alopecia may have insulin resistance, although no significant differences in metabolic syndrome were found compared to controls.
40 citations
,
December 2012 in “Epilepsia” This review discusses the role of δ-subunit-containing GABA A receptors and neurosteroids in temporal lobe epilepsy, highlighting their plasticity and potential pharmacological implications, without reporting new clinical results.
40 citations
,
November 2009 in “Experimental Dermatology” This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.
39 citations
,
January 2012 in “Acta dermato-venereologica” This study examined 27 DRESS patients diagnosed in Thailand, identifying phenytoin, allopurinol, and nevirapine as common causes, with a 3.7% mortality rate and systemic corticosteroids being a common treatment.
38 citations
,
November 2013 in “Journal of The American Academy of Dermatology” This study found that higher BMI was significantly associated with more severe hair loss in men with male-pattern and early-onset androgenetic alopecia.
37 citations
,
February 2017 in “Anais Brasileiros De Dermatologia” In this study, researchers found that the prevalence of androgenetic alopecia was higher in their sample compared to other studies in Asian and Caucasian populations, and it was linked with age-related severity.
37 citations
,
February 2013 in “Maturitas” This review refutes several myths about testosterone therapy in women and suggests that testosterone is beneficial for both physical and mental health, though its safety in women continues to be researched.
36 citations
,
November 2018 in “American Journal of Clinical Dermatology” This review discusses the significant burden of disease and psychosocial implications associated with alopecia, highlighting its comorbidities and the impact on quality of life despite being viewed traditionally as an aesthetic concern, but reports no clinical results.
35 citations
,
January 2014 in “BioMed Research International” This review examines the epidemiology, pathogenesis, clinical manifestations, and diagnosis of female pattern hair loss and reports no new results.
34 citations
,
January 2014 in “Indian Dermatology Online Journal” This study supports evaluating metabolic syndrome and insulin resistance in young males with advanced androgenic alopecia to potentially reduce future cardiovascular and type 2 diabetes risks.
33 citations
,
November 2012 in “Journal of The American Academy of Dermatology” This study reported that female pattern hair loss was prevalent in 11.8% of women aged 30 and older and was associated with high fasting glucose, fewer childbirths, oral contraceptive use, and excessive ultraviolet exposure.
30 citations
,
September 2017 in “Clinics in Dermatology” This review explores the relationship between androgenetic alopecia and metabolic syndrome, suggesting an association that supports considering cardiovascular risk assessments in patients with this type of hair loss.
28 citations
,
July 2017 in “Journal of Endocrinological Investigation” This study suggests that early onset androgenetic alopecia in men may indicate a male PCOS equivalent, possibly leading to higher risks of metabolic and cardiovascular disorders later in life.
26 citations
,
October 2018 in “Clinical & Translational Oncology” This review outlines dermatological toxicities associated with targeted cancer therapies and immunotherapies, emphasizing the need for collaborative management by oncologists and dermatologists but reports no new clinical findings.
25 citations
,
July 2019 in “Experimental Dermatology” This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.
21 citations
,
January 2015 in “Oncology Research and Treatment” This study found that sensor-controlled scalp cooling was effective in preventing hair loss during chemotherapy, particularly in premenopausal patients and those without systemic comorbidities or additional medications.
21 citations
,
March 2013 in “Cancer Epidemiology, Biomarkers & Prevention” This study found that early-onset baldness in African-American men is associated with an increased risk of developing prostate cancer and more aggressive tumors, with potential interactions involving age and smoking.
21 citations
,
November 2012 in “Plastic and Reconstructive Surgery” The researchers reported that various environmental factors and higher testosterone levels were linked to different patterns of hair loss in women with androgenic alopecia.
20 citations
,
July 2020 in “Expert Opinion on Biological Therapy” This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.
20 citations
,
October 2018 in “American Journal of Clinical Dermatology” This article reviews drug-induced pigmentation and reports no new clinical findings, highlighting difficulty in confirming drug associations due to factors like delayed onset and polypharmacy.