Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This case report describes a 61-year-old Italian man with a rare, localized variant of junctional epidermolysis bullosa linked to the R795X mutation in the COL17A1 gene, highlighting the importance of precise diagnosis for effective management of rare genetic disorders.

This study suggests a potential genetic component in CFA among Ridgeback dogs, but MLPH genotyping did not identify the MLPH gene as a contributing factor.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

This study found that the compound M50054 inhibits apoptosis by blocking caspase-3 activation and may improve chemotherapy-induced alopecia and hepatitis symptoms.

This study identifies specific molecular components involved in the intracellular trafficking of LGR5, revealing mechanisms that differ from typical GPCR recycling processes.

This study identified a 505-bp indel variant in the FGF5 gene associated with cashmere growth in goats, which may serve as a molecular marker in cashmere goat breeding programs.

This case report describes a 12-year-old boy with severe skin scaling due to novel compound heterozygous null truncation mutations in the TGM1 gene, resulting in loss of transglutaminase 1 activity.

In this study, the SRD5A2 rs523349 polymorphism was significantly associated with an increased risk of miscarriage, particularly during the second trimester.

This study found that NB-002 demonstrated clear antifungal activity and clinically significant nail clearing in subjects with distal subungual onychomycosis and ≤50% nail involvement, compared to a vehicle treatment.

This study identified a novel recessive mutation in mice causing lethal congenital lamellar ichthyosis, with skin and hair follicle alterations similar to human congenital ichthyoses, linked to a specific genetic defect affecting Fatp4.

In this study, Nd:YAG picosecond lasers using fractional micro-lens array were found to have a comparable effect to ablative fractional Er:YAG lasers in treating atrophic acne scars, with better safety profiles but slightly less patient satisfaction.

This study found that knocking out the transactivation domain of Miz1 in mouse keratinocytes disrupted hair follicle orientation, caused irregular pigmentation, and increased keratinocyte proliferation, indicating Miz1's role in hair follicle development and morphogenesis.

This review discusses the evolution and development of smart and multifunctional microneedles, highlighting their potential future importance in medical applications, but it reports no new experimental results.

This study characterized the mouse profilaggrin gene, finding it structurally identical to its human counterpart, and noted differences in protein-coding regions that could impact epidermal differentiation.

This study concluded that the combination of all-trans-retinoic acid and tocopherol-α is not recommended for treating del(5q) myelodysplastic syndromes due to low efficacy and high incidence of adverse effects.

This study found that LGR5 may play a significant role in maintaining brain cancer stem-like cells and is associated with glioma progression and poor outcomes.

Alpha-MSH affects mitochondrial function, and MC1R mutations may increase skin aging.

This study reported the development of a workflow that combines SIMS and X-ray elemental mapping techniques for multimodal imaging at the single cell level, successfully applied to visualize elements, metals, and lipids in porcine skin without loss or delocalization.

In this randomized study, BAY 1158061, a prolactin receptor antibody, was found to be safe, well-tolerated, and exhibited low immunogenicity in healthy postmenopausal women, but had no effect on serum prolactin levels compared to placebo.

This study revealed distinct cellular and transcriptomic differences among various subtypes of cutaneous T-cell lymphoma, particularly highlighting characteristics unique to folliculotropic mycosis fungoides.

This article suggests that eyelash prostheses may exacerbate isotretinoin-induced blepharitis, highlighting the need for caution among young women using both products.

This study reported that a novel vasodilator drug called TOP-M119, when delivered using a specially designed dissolving microneedle system, showed enhanced targeting of hair follicles and effectiveness in treating alopecia, demonstrated through in vitro, ex vivo, and in vivo studies involving mouse skin.

This phase II trial found that BI 2536 demonstrated limited antitumor activity across five solid tumor types, with no confirmed objective responses observed.

This study developed a co-design framework using finite element analysis to optimize bubble microneedles, achieving controlled tip separation and effective drug delivery through the skin and mucosa while maintaining insertion strength.

MK-386 and finasteride together effectively reduce DHT levels, potentially treating acne and male pattern baldness.

This study demonstrated that a microarray patch can deliver antibodies in a controlled and prolonged manner, maintaining their functionality after manufacturing and heat exposure, with successful pharmacokinetic proof-of-concept in rats.

In this study, Nε-(carboxymethyl) lysine was found to weaken hair follicle morphogenesis and inhibit essential cell activities in a model simulating accumulated glycation.

This study describes a new intravital microscopy method for observing intestinal regeneration by tracking crypt dynamics in living mice after laser-induced tissue damage, revealing events like crypt fission, fusion, and disappearance over multiple weeks.