53 citations
,
April 2014 in “Experimental Dermatology” In this study, ectopic Wnt10b-mediated β-catenin activation in hair follicles resulted in larger regenerating anagen hair structures, an effect modulated by the Wnt inhibitor DKK1.
53 citations
,
September 2011 Other common signs, not just the well-known immune cells around hair bulbs, are important for diagnosing hair loss from alopecia areata.
52 citations
,
April 2004 in “Journal of The American Academy of Dermatology” This article proposes three mechanisms by which dihydrotestosterone may contribute to baldness but reports no new research findings.
40 citations
,
May 2012 in “British Journal of Dermatology” This study reviewed scalp biopsies from African-American patients, identifying distinct features and diagnostic clues for scarring alopecia types such as traction alopecia and central centrifugal cicatricial alopecia.
40 citations
,
June 2009 in “Journal of Cutaneous Pathology” This study found that Iranian patients with androgenetic alopecia had a higher terminal to vellus hair ratio compared to previous studies in Whites, suggesting potential onset of miniaturization.
37 citations
,
October 2014 in “Maturitas” This review discusses the mechanisms and treatment strategies for age-related hair changes, such as androgenetic alopecia and hair graying, and reports no new clinical results.
31 citations
,
September 2009 in “Natural Product Research” In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.
20 citations
,
August 2005 in “Journal of Cutaneous Pathology” This study found that in male androgenic alopecia, the androgen receptor coactivator ARA70/ELE1 exhibits differential expression patterns, suggesting its involvement in the condition.
19 citations
,
September 2014 in “JAMA Dermatology” Eosinophilic infiltrate is not a reliable indicator for diagnosing chronic alopecia areata.
17 citations
,
January 2011 in “Skin Research and Technology” Hair from people with seborrheic dermatitis is thicker scaled, more damaged, and thinner than healthy hair, and atomic force microscopy can help monitor the condition.
17 citations
,
December 2004 in “The Journal of Men's Health & Gender” This article discusses the role of androgens in hair follicle changes, explaining how dihydrotestosterone contributes to hair thinning on the scalp, while promoting thicker facial hair in men, and reports no new clinical results.
16 citations
,
October 2012 in “British Journal of Dermatology” Chemotherapy can cause significant hair thinning and changes in hair texture, while tamoxifen has a smaller effect.
11 citations
,
April 2020 in “Journal of The American Academy of Dermatology” This commentary reviews the evidence for microinflammation's role in pattern hair loss and suggests that further studies with age- and sex-matched controls are needed to substantiate the findings.
8 citations
,
August 2014 in “Clinical and Experimental Dermatology” This study found that chronic telogen effluvium is a distinct condition from female pattern hair loss, with different pathogenic mechanisms observed in histomorphometric analyses.
4 citations
,
January 2018 in “Advances in Experimental Medicine and Biology” This article discusses the structures surrounding hair follicles and introduces aspects like follicle groups and the dermal sheath, but it reports no new research findings.
4 citations
,
November 2004 in “Clinical and Experimental Dermatology” This study identified a new class of shed hair in young women that could impact future hair research and suggests that the concept of hair miniaturization in androgenetic alopecia may need revision.
1 citations
,
April 2021 in “Clinical, Cosmetic and Investigational Dermatology” This review proposes that inconsistent findings in androgenic alopecia research are due to variable biopsy location, hair diameter diversity, and hair follicle miniaturization, and suggests ways to improve study methods.
April 2026 in “Frontiers in Immunology” This study concluded that the CXCL12–CXCR4 signaling pathway significantly contributes to hair loss in androgenetic alopecia and alopecia areata by promoting inflammation and fibrosis, whereas inhibiting this pathway can restore hair growth and follicle health.
June 2024 in “Research Square (Research Square)” This study identified a network of interactions between miRNAs and mRNAs that involve key signaling pathways, suggesting new insights into the mechanisms behind androgenetic alopecia.
June 2016 in “Experimental Dermatology” This study highlights the significance of SFRP2 expression in dermal papilla cells, noting its correlation with the inductive potential for hair growth, although its role may be more indicative than transformative.
March 2026 in “Frontiers in Medicine” This study reported that two male patients with diffuse unpatterned alopecia exhibited donor-area involvement in both the vertex and occiput, challenging the assumption of occipital stability for hair transplantation, and showed partial improvement following treatment with oral finasteride and topical minoxidil.
March 2026 in “Reports of Vinnytsia National Medical University” This study examined young Ukrainian men with alopecia areata and found that different severities of the condition were associated with distinct clinical and trichoscopic features, such as variations in hair loss, stress levels, and nail involvement, among others.
February 2026 in “Editora Pasteur eBooks” An integrative approach combining medical, nutritional, and lifestyle changes effectively manages female pattern hair loss.
30 citations
,
December 2017 in “Clinical, Cosmetic and Investigational Dermatology” This study found significant differences in hair density, non-vellus hair diameter, and percentage of miniaturized hair between normal women and those with female pattern hair loss, particularly in the midscalp and parietal areas.
2 citations
,
August 2017 in “British Journal of Dermatology” Hair loss in Cronkhite-Canada syndrome may be due to an autoimmune response.
December 2024 in “Australian Journal of General Practice” In this case report, a 20-year-old woman exhibited progressive asymptomatic hair loss with a pattern inconsistent with alopecia areata or female pattern hair loss, showing areas of both extending and improving hair loss.
January 2020 in “Revista Dermatológica Centro Uraga” This article describes how recognizing distinct trichoscopic features aids in diagnosing various dermatological conditions and hair loss, but it reports no new clinical findings.
42 citations
,
March 2006 in “Drug Discovery Today: Therapeutic Strategies” This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.
27 citations
,
January 2017 in “Indian Dermatology Online Journal” This study found no significant benefit from PRP injections for treating androgenetic alopecia in men, highlighting the need for larger, well-designed trials to assess its effectiveness and safety.
23 citations
,
October 2021 in “Cell Stem Cell” This study found that hair shaft miniaturization in aging and genetic hypotrichosis leads to hair follicle stem cell loss through mechanical compression and apoptosis mediated by the Piezo1 channel.