July 2025 in “Ultrasound in Medicine & Biology” This study found that nanobubble-encapsulated diclofenac with ultrasound-targeted microbubble destruction (DNBs-UTMD) can enhance the anti-tumor efficacy of Doxil® by regulating the tumor immune microenvironment, improving drug uptake, and increasing T cell responses while reducing immune-suppressive cells in the process.
December 2020 in “Nippon Laser Igakkaishi” This review covers the mechanisms and reported clinical effects of Photobiomodulation therapy, particularly in the fields of plastic surgery and dermatology, without presenting new clinical results.
1 citations
,
June 2025 in “Therapeutic Delivery” This article reviews microneedle technology as a transdermal drug delivery platform without presenting new clinical results, emphasizing its engineered microstructure arrays for enhanced penetration.
2 citations
,
March 2024 in “Pharmaceutics” This study demonstrated that while the proposed placebo microneedle stamp design was partially successful in blinding participants with low skin sensitivity, further development of suitable placebo controls is needed.
108 citations
,
August 2017 in “Clinical, Cosmetic and Investigational Dermatology” This review highlights microneedling's promise as an adjuvant therapy for enhanced drug delivery in dermatology, especially for conditions like atrophic scars and pigmentation disorders, though its efficacy for vitiligo is limited.
1 citations
,
January 1987 This study found that low-output laser irradiation demonstrates biostimulatory effects on several biological systems and processes, including hair growth, wound healing, and immune function, with effects influenced by dose and exhibiting both stimulatory and inhibitory potential.
7 citations
,
March 2021 in “IntechOpen eBooks” In this chapter, the authors provide a detailed overview of the fundamental science and operational principles of radiofrequency technologies, particularly in enhancing liposuction procedures through minimally-invasive techniques like RF-assisted lipolysis and fractional RF subdermal treatment.
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that low-level pulsed wave red light stimulated collagen and ATP production in human fibroblasts with significantly shorter treatment time than continuous wave light, suggesting enhanced consumer compliance for skin treatments.
June 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” This study tested a microneedle patch on rabbit and pig models to support skin regeneration, revealing that the treatment accelerated wound closure, reduced scar formation, and promoted hair-bearing tissue and follicle growth, suggesting a trauma-guided framework for skin restoration.
2 citations
,
July 2004 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study found that multiple treatments combining NIR laser phototherapy with ICG significantly reduced inflammation and improved skin condition in acne without side effects.
9 citations
,
November 2022 in “Journal of Cosmetic Dermatology” Among patients treated at Thomas Jefferson University, this study found that adding cryotherapy to intralesional triamcinolone acetonide (IL TAC) was more effective at reducing keloid size compared to IL TAC alone, although both treatments similarly eased pruritus and pain.
8 citations
,
March 2025 in “Journal of Drug Delivery Science and Technology” Dissolvable microneedles are a promising, painless method for effective skin treatments.
August 2026 in “Journal of Maxillofacial and Oral Surgery” This study investigated treatments for male androgenetic alopecia, finding that combining injectable platelet-rich fibrin (i-PRF) with microneedling increased hair growth more effectively than i-PRF alone according to questionnaires and photographic assessments.
February 2025 in “Cosmetics” This narrative review explored how blue light therapy may offer therapeutic benefits for various skin disorders by affecting microbial activity and immune responses, promoting hair growth, and aiding skin rejuvenation and healing.
April 2026 in “BioNanoScience” A new microneedle system may improve hair loss treatment by delivering ketoconazole directly to hair follicles.
This review highlights effective non-invasive strategies such as physiotherapy, pharmacological treatments, and Botulinum toxin injections for managing head and neck neuralgias, emphasizing the importance of tailoring treatment to individual needs based on the specific type of neuralgia.
1 citations
,
January 2018 in “Journal of Cosmetic and Laser Therapy” The editorial introduces various topics on laser and cosmetic treatments in a medical journal.
4 citations
,
July 2023 in “Colloids and surfaces. B, Biointerfaces” This study explores novel alopecia treatments targeting lactate dehydrogenase pathways and improving drug delivery through technologies like phototherapy and soluble microneedles, though practical application challenges remain, necessitating further research for clinical use.
9 citations
,
April 2025 in “Stem Cell Research & Therapy” This review suggests that MSC-derived conditioned media hold promise in dermatology, with studies indicating enhanced therapeutic effects when used alongside treatments like laser therapy and microneedling, leading to improved dermatological outcomes.
6 citations
,
November 2018 in “Photodiagnosis and Photodynamic Therapy” This study found that using a wearable low-level light therapy device for photodynamic therapy significantly reduced actinic keratosis lesions and improved quality of life in patients with AK of the scalp.
January 2026 in “Open MIND” This study identified candidate compounds from a natural-product library that may interact with the PIEZO1 and MLCK pathways, potentially countering a non-androgen cause of hair follicle miniaturization, all based on computer simulations; experimental validation is necessary.
November 2024 in “Journal of Cosmetic Dermatology” This study evaluated eyebrow mesotherapy with a growth factor-based cocktail in 32 women with thin eyebrows, finding high satisfaction rates (90.6%) with significant improvements in density and appearance, low pain levels, and unanimous willingness to recommend the treatment.
1 citations
,
September 2019 in “Hair transplant forum international” This article introduces a needleless microjet injector using laser pulse energy for tattoo pigments in scalp micropigmentation, highlighting an almost painless procedure without anesthesia.
5 citations
,
January 2025 in “Aesthetic Surgery Journal Open Forum” In this mouse study, researchers reported that sequential monopolar-bipolar radiofrequency irradiation significantly improved skin quality by increasing collagen density, elastin fiber expression, and fibroblast differentiation more than monopolar RF treatment alone.
198 citations
,
September 2007 in “Clinics in Dermatology” Radiofrequency devices effectively tighten skin without surgery.
In this case series, researchers reported an unexpectedly rapid and positive response to a topical, hydrogel-based botanical treatment for androgenetic alopecia in both male and female volunteers, achieving significant improvement in hair loss within 90 days instead of the planned 270 days.
2 citations
,
January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the effects of low-level laser therapy in various biological processes for wound healing and tissue repair and reports no new results.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This source establishes prior art for treating androgenic alopecia and sexual dysfunction by restoring gap-junction-mediated connectivity in tissue networks, highlighting a mechanism independent of commonly targeted pathways.
1 citations
,
April 2026 in “Aesthetic Plastic Surgery” This study found that radiofrequency microneedling is effective and well-tolerated for improving various skin conditions, showing comparable efficacy to fractional lasers for atrophic acne scars with generally favorable patient satisfaction and safety.
55 citations
,
March 2018 in “Journal of pharmacy & pharmaceutical sciences” This article reviews the applications of microneedle technology in drug delivery, dermatology, and cosmetics, but it presents no new experimental or clinical findings.