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The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Sebocytes play a key role in controlling androgen levels in human skin.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

High androgen levels in young women with PCOS are linked to higher blood pressure.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

The document concludes that while significant progress has been made in understanding skin biology and stem cells, more research is needed to fully understand their interactions with their environment.

Nerves and chemicals in the body can affect hair growth and loss.

A very low-calorie ketogenic diet is effective for quick weight loss and improving health in obese patients, with careful management of side effects and maintenance.

Hormones and metabolism play a complex role in prostate enlargement, and more research is needed to improve diagnosis and treatment.

Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.

The circadian clock is crucial for tissue renewal and regeneration, affecting stem cell functions and having implications for health and disease.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

Eating 500 fewer calories a day and making lifestyle changes can improve PCOS symptoms and reduce diabetes risk; more research is needed on its causes and treatments.

Women with PCOS may take longer to get pregnant but can have a normal family size, and should manage their overall health to reduce long-term health risks.

Changes to the Foxp3 protein affect how well regulatory T cells can control the immune system, which could help treat immune diseases and cancer.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Insulin resistance contributes to hormone imbalances in many women with polycystic ovary syndrome.

Oral contraceptives help treat hyperandrogenic disorders, improving symptoms like excessive hair and acne.

Melatonin may reduce skin damage caused by X-rays in rats.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Insulin resistance linked to obesity may increase COVID-19 severity.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.