September 2008 in “Pediatric Rheumatology” This study reports that the symptoms and immunological findings in two children with diverse autoimmune-like conditions were ultimately attributed to lysinuric protein intolerance, confirmed by genetic analysis in one child.
3 citations
,
May 2023 in “Biomedicines” This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.
4 citations
,
July 2024 in “Journal of Reproduction & Infertility” This study concluded that fenugreek improved lipid profiles in women with PCOS compared to metformin, but cannot substitute metformin for PCOS treatment; it may serve as an adjuvant therapy for those with hyperlipidemia.
1 citations
,
May 2020 in “Reproductive Endocrinology” This review discusses the pathogenesis and diagnosis of alopecia and acne, emphasizing the need for coordinated treatment approaches in conditions like FPHL/AGA and complex acne, but reports no new clinical results.
May 2026 in “International Journal of Current Pharmaceutical Review and Research” This article discusses the causes of polycystic ovary syndrome, including environmental pollutants, genetics, and oxidative stress, and explains how these factors contribute to symptoms like irregular menstrual cycles and obesity without reporting new clinical results.
72 citations
,
October 1988 in “Archives of Disease in Childhood” This study found that while biotin treatment improves clinical and biochemical symptoms in patients with biotinidase deficiency, some experience lasting neurological damage, and it is uncertain if early treatment can prevent this.
2 citations
,
August 2004 This study found that early diagnosis using gas chromatography/mass spectrometry and appropriate long-term treatment are crucial for improving outcomes in patients with methylmalonic acidemia.
1 citations
,
October 2023 in “Journal of personalized medicine” In this study, researchers investigated genetic variants in pharmacogenes affecting tadalafil and finasteride pharmacokinetics, finding fed volunteers had higher drug exposure than fasting individuals, but genetic variation did not significantly impact pharmacokinetics after correcting for multiple comparisons.
May 2009 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study suggests that decreased PPARgamma function may trigger the pathogenesis of lichen planopilaris, and PPARgamma-targeted therapy could be a potential treatment method.
January 2025 in “Japanese Journal of Gastroenterology and Hepatology” This study found that non-alcoholic fatty liver disease was prevalent among women with polycystic ovarian syndrome and was linked to higher BMI, waist/hip ratio, testosterone levels, and deranged lipid profile.
February 2022 in “International journal of research in dermatology” This case series describes seven distinct hair shaft disorders, highlighting the importance of accurate diagnosis since these conditions are often treated incorrectly as alopecias without improvement.
75 citations
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June 1999 in “Pediatric Clinics of North America” This review discusses the clinical features and therapeutic goals for teenagers with PCOS, emphasizing the need for further research into its causes and potential long-term health risks, but reports no new clinical results.
November 2024 in “IP Indian Journal of Clinical and Experimental Dermatology” This study discusses the multifactorial causes of metabolic syndrome and its association with various skin conditions, indicating an increased risk of diabetes and cardiovascular issues, emphasizing the need for early lifestyle interventions and medical management.
26 citations
,
July 2012 in “Endocrine Connections” This study found that mitotane causes specific changes in cortisol metabolism, including increased excretion of certain metabolites, which may influence cortisol bioavailability without hindering early detection of adrenocortical carcinoma recurrence.
53 citations
,
September 2014 in “Reproductive Biology and Endocrinology” This study observed that among women with polycystic ovary syndrome, those with the most severe phenotype showed the highest levels of metabolic disturbances, indicating the need for metabolic screening in these cases.
1 citations
,
April 2019 in “Acta medica Philippina” This study found that androgenetic alopecia is significantly associated with an increased risk of Metabolic Syndrome, particularly in early-onset male cases and females exhibiting severe AGA.
December 2025 in “Bali Dermatology Venereology and Aesthetic Journal” This narrative review emphasizes the relationship between metabolic syndrome, metabolic aging, and skin manifestations, highlighting cases like early-onset androgenetic alopecia linked with insulin resistance, and underscores their significance for dermatology and aesthetic practice.
The authors of this study concluded that higher calcium levels in hair may indicate early metabolic changes leading to osteopenia or osteoporosis in menopausal women, even before detectable by standard DEXA imaging.
202 citations
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January 1989 in “Journal of Clinical Investigation” This study indicates that insulin changes sex hormone levels in insulin-resistant women with polycystic ovary syndrome without affecting gonadotropin release, challenging the idea that hyperinsulinemia directly causes hyperandrogenism in PCO.
44 citations
,
September 2020 in “International Journal of Molecular Sciences” This review discusses the disruption of hormonal and metabolic rhythms in polycystic ovary syndrome and explores potential drug targets to address its molecular causes, without providing new clinical results.
2 citations
,
June 2016 in “Journal of skin and stem cell” This study found that wet cupping blood differs significantly from venous blood in metabolite profiles, implying distinct biochemical pathways may be involved.
December 2025 in “Zenodo (CERN European Organization for Nuclear Research)” This paper introduces the Vertex Overload Framework for androgenetic alopecia, suggesting that chronic mechanical and thermal stress on the vertex contributes to hair follicle miniaturization, with androgens acting as co-mediators of stress adaptation rather than isolated causes.
1 citations
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January 2016 in “Companion animal” This article reviews the causes and diagnostic approaches for feline alopecia, emphasizing the importance of distinguishing between self-inflicted and spontaneous hair loss, but reports no new results.
March 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This report reviews the causes, symptoms, diagnosis, complications, and treatment options for Polycystic Ovarian Disease, emphasizing the importance of early diagnosis and individualized management, but it does not provide new research findings.
January 2023 in “Sibirskij medicinskij vestnik” This analysis explores possible causes of menstrual irregularities in women with PCOS following COVID-19, but reports no new clinical findings.
This article discusses various potential causes of hair loss in women undergoing renal replacement therapy and emphasizes the importance of thorough patient evaluation, but it reports no new research findings.
January 2022 in “Springer eBooks” The book explains causes and treatments for common hair loss, its psychological effects, related health risks, and emphasizes early screening and lifestyle changes.
53 citations
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June 2012 in “Annales d'Endocrinologie” This review discusses the range and causes of adipose tissue diseases, emphasizing genetic and acquired forms of lipodystrophy, but it reports no new clinical results.
October 2015 in “CRC Press eBooks” This article reviews the diagnosis and causes of different types of alopecia, presenting no new clinical findings.
June 2015 in “Obstetrics, gynaecology and reproductive medicine” This article reviews the causes, physiology, and treatment strategies for hirsutism in women, highlighting that effective management often requires addressing underlying conditions and may involve lifestyle changes and pharmacological interventions.