Effects of Mitotane Treatment on Human Steroid Metabolism: Implications for Patient Management

    July 2012 in “ Endocrine Connections
    Lea Ghataore, Indrani Chakraborti, Simon Aylwin, Klaus‐Martin Schulte, Dorota Dworakowska, Patsy Coskeran, Nicholas F. Taylor
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    Studysummary This study found that mitotane causes specific changes in cortisol metabolism, including increased excretion of certain metabolites, which may influence cortisol bioavailability without hindering early detection of adrenocortical carcinoma recurrence.
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