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    Glossary MEK inhibitors

    block enzymes involved in cell growth signaling pathways

    MEK inhibitors, also known as MEKis or MEK1/2 inhibitors, are a class of drugs that block the activity of the MEK enzymes (MEK1 and MEK2), which are part of the MAPK/ERK signaling pathway. This pathway is crucial for cell division and survival, and its dysregulation is often implicated in various cancers. By inhibiting MEK, these drugs can help to slow down or stop the growth of cancer cells.

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    Research 30 of 416

    1. Cutaneous Toxicities of MEK Inhibitor Use in Children: A Comparison of Binimetinib and Selumetinib Pediatric Dermatology · 2024 · 3 citations
    2. Melanotic pigmentation in excisional scar of melanoma patient who received BRAF and MEK inhibitors Journal of The American Academy of Dermatology · 2018 · 1 citations
    3. 422 Human hair follicles express PD-L1, whose expression is down-regulated by EGFR and MEK inhibitors ex vivo. A potential mechanism for EGFR inhibitor induced sterile folliculitis Journal of Investigative Dermatology · 2019
    4. 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes Journal of Investigative Dermatology · 2016
    5. 861 EGFR/MEK inhibitor therapy induces partial hair follicle immune privilege collapse in vivo and ex vivo Journal of Investigative Dermatology · 2022
    6. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes 2019 · 32 citations
    7. 645 MIG6 is MEK-regulated and affects EGF-induced migration in mutant NRAS melanoma Journal of Investigative Dermatology · 2016
    8. Continuous MEK inhibition by AZD6244 (ARRY-142886) results in exhaustion of the cutaneous keratinocytic stem cell pool and resembles senescence driven skin aging Journal of Clinical Oncology · 2008 · 2 citations
    9. The incidence and management of cutaneous adverse events of the epidermal growth factor receptor inhibitors Postępy Dermatologii i Alergologii · 2017 · 18 citations
    10. Cutaneous toxicities of new treatments for melanoma Clinical & Translational Oncology · 2018 · 25 citations
    11. Dermatologic adverse events associated with chemotherapy and targeted anticancer therapy Dermatology Review · 2016 · 4 citations
    12. When bugs and drugs conspire: driving acneiform skin toxicity 2020 · 1 citations
    13. Adverse Hair Reactions to New Targeted Therapies for Cancer Actas Dermo-Sifiliográficas · 2019 · 1 citations
    14. 642 Uncovering the role of UV exposure history and genetics in determining skin sun damage Journal of Investigative Dermatology · 2016 · 1 citations
    15. Papulopustular eruptions associated with EGFR-pathway-related targeted therapies: clinical spectrum, evidence boundaries, folliculocentric inflammation, and management considerations Frontiers in Oncology · 2026
    16. Cutaneous Side Effects of Modern Targeted Therapy and Immunotherapy in Patients with Dermatological Malignancies Cancers · 2023
    17. Dermatologic Side Effects of Systemic Targeted Anticancer Therapy Springer eBooks · 2018
    18. Cutaneous Drug Eruptions Associated with the Use of New Oncological Drugs 2012 · 29 citations
    19. Dihydrotestosterone Induces Keratinocyte Apoptosis by Activating ERK Signaling In Vivo · 2026
    20. Sorafenib-induced eruption resembling pityriasis rubra pilaris Journal of the American Academy of Dermatology · 2011 · 21 citations
    21. Cutaneous adverse effects of targeted therapies Journal of the American Academy of Dermatology · 2015 · 149 citations
    22. The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis Cutaneous and Ocular Toxicology · 2018 · 9 citations
    23. The spectrum of cutaneous adverse events during encorafenib and binimetinib treatment in B‐rapidly accelerated fibrosarcoma‐mutated advanced melanoma Journal of the European Academy of Dermatology and Venereology · 2018 · 21 citations
    24. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    25. 329 Mechanisms of Cutaneous Adverse Events during Targeted Cancer Therapy 2022
    26. Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice Hippocampus · 2009 · 85 citations
    27. Management of Dermatologic Toxicities Journal of the National Comprehensive Cancer Network · 2015 · 12 citations
    28. Progesterone Promotes the Survival of Newborn Neurons in the Dentate Gyrus of Adult Male Mice Acta Universitatis Medicinalis Nanjing · 2010
    29. RASopathic Skin Eruptions during Vemurafenib Therapy PLoS ONE · 2013 · 82 citations
    30. Multimodal therapeutic approach for a severe case of kaposiform lymphangiomatosis from procedural interventions to targeted therapies Pediatric Blood & Cancer · 2024 · 1 citations