Persistently Curly Hair Phenotype With the Use of Nivolumab for Squamous Cell Lung Cancer

The document described the first reported case of a persistent curly hair phenotype in a patient with metastatic squamous cell lung cancer treated with nivolumab, a programmed cell death protein 1 (PD-1) inhibitor. While cutaneous side effects such as pruritus, vitiligo, and lichenoid skin eruptions were known for PD-1 inhibitors, alopecia had been the only hair-related effect previously documented. This case highlighted a novel and puzzling side effect, expanding the spectrum of dermatologic reactions associated with immune checkpoint inhibitors.