June 2026 in “Communications Biology” In this study, researchers found that the cornification process in the nuptial pads of Xenopus frogs involves the expression of the type II hair keratin homolog, krt59, and is regulated by the transcription factor hoxc13, showing similarities to mammalian hair evolution.
This study found that depleting fibroblasts in the skin does not affect the proliferative capacity of epidermal stem cells at various ages, suggesting robust compensatory mechanisms maintain skin functionality despite these cellular changes.
September 2025 in “American Journal of Dermatopathology” In this research, most cases of mammary and extramammary Paget disease were reported to express PRAME, expanding the understanding of its presence in cutaneous epithelial tumors, though its diagnostic utility is limited by overlap with other conditions.
August 2024 in “STAR Protocols” This study details a step-by-step protocol for preparing mammalian skin samples, including hair follicles, for spatial transcriptomics to overcome challenges inherent in applying this technique to the skin.
August 2024 in “Biophysics Reviews” This study explores the physical properties of hair from various wild mammalian species using polarized light microscopy, aiming to correlate these properties with the internal structures such as the medulla, cortex, and keratin cuticle.
September 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study describes the use of a genetically engineered mouse model, mTurquoise2-Col4a1, to fluorescently label collagen IV and observe basement membrane dynamics during skin development, revealing its stability and pliability during rapid growth phases.
September 2022 in “Research Square (Research Square)” This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.
November 2020 in “IntechOpen eBooks” This review discusses the role of mineral nutrients in human health, emphasizing the importance of dietary sources and education to prevent mineral deficiencies, and reports no new clinical results.
January 2016 in “Columbia Academic Commons (Columbia University)” This article explores the evolution of mechanosensing and discusses the diverse forms and organization of touch receptors but reports no new research findings.
October 1990 in “Spectrum Research Repository (Concordia University)”
252 citations
,
February 2018 in “npj Regenerative Medicine” This review explores recent advances in understanding molecular mechanisms of tissue regeneration in mammals and suggests potential therapeutic targets, but it reports no new clinical results.
182 citations
,
August 2016 in “Development” This review discusses the roles and mechanisms of chromatin remodelers and their subunits in mammalian development, but reports no new experimental results.
93 citations
,
June 2011 in “Journal of Neuroscience” This study found that the transcription factor p63 is crucial for horizontal basal cell differentiation in the olfactory epithelium, suggesting a p63-dependent mechanism activates reserve stem cells after injury.
92 citations
,
March 2010 in “Gerontology” This review discusses the regenerative processes of deer antlers compared to other vertebrates and reports no new experimental findings, suggesting insights for regenerative medicine and cancer biology.
91 citations
,
December 2006 in “Proceedings of the National Academy of Sciences” In this study, researchers found that hair follicle orientation in Fz6 −/− mice is disrupted and that hair may reorient itself over time through a self-organized process.
79 citations
,
November 2016 in “EMBO Reports” This review evaluates methods to study stem cell division patterns, particularly in the mammary gland, and discusses genetic factors affecting division modalities and their implications for breast cancer, but reports no new results.
44 citations
,
January 1984 in “Molecular and Cellular Biochemistry” 38 citations
,
April 2016 in “The Journal of Pathology” This study found that mice lacking alkaline ceramidase 1 with elevated skin ceramide levels showed disrupted skin homeostasis, including altered hair follicle structures, increased water loss, and a hypermetabolism phenotype.
30 citations
,
January 1994 in “Micron” This study found that the formation of the fibre cuticle surface in Merino sheep is similar to the epidermal stratum corneum process and not from a modified plasma membrane as previously thought.
27 citations
,
August 2013 in “Cell Proliferation” This review discusses key signaling pathways involved in tooth formation, highlighting their role in understanding tooth regeneration and potential therapies for dental abnormalities.
16 citations
,
November 2022 in “eLife” This study found that specific genetic changes in both coding and noncoding regions may have independently driven the evolution of hairlessness in various mammalian species through accelerated evolution.
15 citations
,
July 2015 in “Journal of exotic pet medicine” This review discusses the prevalence, diagnosis, treatment, and prevention of zoophilic dermatophyte infections in small exotic mammals and reports no new clinical findings; it emphasizes the need for veterinary guidance and public awareness.
13 citations
,
January 1987 in “Dermatology” This study observed that the active metabolite minoxidil sulfate promotes vascular relaxation by enhancing potassium permeability, which may inform understanding of minoxidil's antihypertensive and hair growth effects.
7 citations
,
May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology” 7 citations
,
January 1995 in “The Indian Journal of Animal Sciences” This study observed that buffalo teats have a melanin-rich epidermis, no hair follicles, and a complex structure with specific epithelial and muscular characteristics.
6 citations
,
April 2010 in “The American Journal of Surgical Pathology” This report highlights two cases where trichoblastoma in the breast was initially misdiagnosed as malignancy due to diagnostic challenges in needle core biopsies, emphasizing the importance of expert dermatopathologic review.
5 citations
,
April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that in adult mice, a cell-autonomous size control mechanism involving the RB pathway determines the timing of S phase entry in epidermal stem cells based on their size, while external microenvironment factors influence growth rates but not this intrinsic coupling.
5 citations
,
June 2011 in “PLoS ONE” This study found that biologic rhythms in mammoth hairs differed from those in modern human hair, with variations in growth rates and mineral content providing insights into the lifestyle and behavior of extinct species.
3 citations
,
November 2022 in “Experimental dermatology” This article discusses melatonin's role in mammalian coat color and its potential in melanoma treatment when used with chemotherapy, but reports no new clinical results.
3 citations
,
January 1984