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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Hair color loss can indicate the effectiveness of a drug targeting the KIT protein in mice and humans.

A 65-year-old woman has a growing bald spot on her scalp.

Reproductive hormones play a crucial role in breast cancer development and treatment challenges.

Epirubicin is as effective as doxorubicin for cancer treatment with less heart damage, but doesn't work on doxorubicin-resistant cancers.

PLD is an effective and safer alternative for treating breast cancer.

Doxil showed some effectiveness against advanced prostate cancer but caused severe side effects at higher doses.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

New chemotherapy drugs cause skin side effects, but treatments like minocycline and tetracycline can help reduce them.

The document concludes that systemic therapy is becoming more important in treating head and neck cancer, with new treatments showing promise.

The document concludes that hirsutism can be managed with various treatments tailored to the individual, potentially improving quality of life.

There is no significant link between insulin resistance and certain hair disorders like idiopathic hirsutism and androgenic alopecia.

Hair loss is a common side effect of hormone treatments for cancer.

Hair loss is a common, often overlooked side effect of hormone treatments for breast and prostate cancer.

MPA increases cancer spread by boosting Eph A2 activity.

Some cancer and immune system drugs can cause serious side effects, including heart, lung, nerve, and organ damage, which need careful monitoring and management.

Chemotherapy can cause various skin reactions, with hair loss being the most common, and proper diagnosis and treatment of these reactions are important.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Cepharanthine is a well-tolerated drug with multiple medical uses, including anti-inflammatory and anti-cancer properties.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Etoposide is effective in treating several cancers, especially small cell lung cancer, with acceptable side effects.

Insulin resistance may contribute to various skin diseases and treating it could improve skin health and prevent more serious conditions.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

Tissue-resident memory T cells can protect against infections and cancer but may also contribute to autoimmune diseases.

Endocrine therapies for cancer significantly increase the risk of hair loss.

Certain hormone treatments can improve acne and related conditions in women.

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Proper control of β-catenin activity is crucial for development and preventing diseases like cancer.