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This study found that culturing fibroblasts on stiffer substrates mimicking fibrotic wounds led to an aligned EDA fibronectin matrix with thinner fibers and decreased YAP activity, suggesting disrupted signaling that might be restored to promote regenerative wound repair.

This study found that frontal fibrosing alopecia involves distinct molecular changes, such as downregulation of steroid and cholesterol pathways and upregulation of fibrotic and immune response genes, which may help guide treatment strategies.

This study used fibre optic confocal imaging to visualize subsurface structures in live mouse skin, revealing cellular details and blood vessel networks that dynamic events could be studied in vivo.

In this study, researchers found that patients with Friedreich's ataxia exhibited more pronounced ultra-structural hair alterations compared to carriers, likely due to oxidative stress related to deficient frataxin expression.

This study found that in murine dermis, fibroblast state switching between proliferation and ECM deposition plays a crucial role in tissue architecture and wound healing.

This study observed that ECMs produced by papillary fibroblasts showed the largest fibers and supported keratinocyte differentiation better than reticular fibroblast matrices, informing biomimetic material design for skin tissue engineering.

This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.

Hair follicles form hard α-keratin filaments in four steps, showing structural differences.

In this study, myofibroblasts in rat cutaneous fibrosis were characterized by expressions of vimentin, α-SMA, and Thy-1, and may derive from pericytes or perifollicular dermal sheath cells.

This review discusses the roles of fibroblasts in foreign body response and highlights the need for further research on their specific functions to improve antifibrotic and regenerative therapies.

This review discusses the heterogeneity of dermal fibroblasts in healthy mouse and human skin and reports no clinical results; the authors highlight potential insights into physiological and pathological wound healing.

Fibronectin is essential for hair follicle regeneration and may help rejuvenate aged skin.

The researchers in this study identified molecular mechanisms involved in frontal fibrosis alopecia, highlighting immune response and fatty acid metabolism, and developed a four-gene diagnostic model showing high accuracy in distinguishing affected individuals from controls.

This study found that the Arabidopsis thaliana protein Formin 2 localizes to plasmodesmata and is crucial for regulating their permeability by anchoring actin filaments, which affects virus susceptibility.

Reactive lipids from aging cells change the extracellular matrix, affecting cell function and inflammation.

This study found that fibronectin nanofiber dressings, made using rotary jet spinning, accelerated wound healing and improved tissue restoration in a full-thickness wound mouse model.

This article reviews the regulation of gene expression and assembly of intermediate filaments but presents no new findings.

This study observed that mink dermal collagen fibrils undergo structural changes during the hair cycle, with increased fiber thickness and bundle density as minks grow.

This paper reports on the structural characteristics of α-type filaments in the inner root sheath cells of guinea pig hair follicles without presenting new clinical findings.

This study used single-cell RNA-sequencing data from mouse skin to reveal that fibroblasts show high transcriptional plasticity during wound healing, forming transient microniches early on and stratifying scar tissue into distinct molecular layers over time.

This study found that FGF-9 treatment in diabetic mice improved heart function after myocardial infarction by decreasing monocyte infiltration and promoting anti-inflammatory macrophage differentiation.

This research discusses the diverse populations and specialized roles of dermal fibroblasts in human skin, highlighting their distinct interactions and contributions to skin structure, without presenting new clinical findings.

This study identified two cell surface markers, FAP and CD90, that distinguish between papillary and reticular fibroblasts in human skin, suggesting distinct functions and distribution in dermal layers.

In this study, researchers used atomic force microscopy to capture and analyze morphological changes in the surface of healthy hair, identifying features such as pitting and rod-shaped macro-fibrillar elements, which could inform future research on hair conditions and care.

This study observed that amelanotic melanocytes from human hair follicles appeared morphologically immature, suggesting they might not transfer melanosomes into keratinocytes.

This study suggested that MRF may support skin regeneration and rejuvenation by promoting collagen synthesis and regulating factors involved in fibroblast activation and ECM remodeling, with preliminary findings indicating ADSCs might aid these processes.