EDA Fibronectin Microarchitecture and YAP Translocation During Wound Closure

    September 2024
    Jennifer Patten, Patrick D. Halligan, Ghazal Bashiri … Karin Wang
    Studysummary This study found that culturing fibroblasts on stiffer substrates mimicking fibrotic wounds led to an aligned EDA fibronectin matrix with thinner fibers and decreased YAP activity, suggesting disrupted signaling that might be restored to promote regenerative wound repair.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on biorxiv.org →
    Discuss this study in the Community →

    Research cited in this study 4

    1. Production-Scale Fibronectin Nanofibers Promote Wound Closure and Tissue Repair in a Dermal Mouse Model Biomaterials · 2018
    2. Integrin Signaling Regulates YAP/TAZ to Control Skin Homeostasis Development · 2016
    3. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007