Dermal Fibroblasts: Terminology, Heterogeneity of Subpopulations, and Common Properties

This review explores fibroblast heterogeneity in the mammalian dermis and suggests potential therapeutic applications by targeting fibroblast subtypes, but reports no new experimental results.

This review discusses the heterogeneity of dermal fibroblasts in healthy mouse and human skin and reports no clinical results; the authors highlight potential insights into physiological and pathological wound healing.

In this source, recent single-cell RNA-sequencing advances reveal significant transcriptional heterogeneity among skin fibroblasts, and the discussion focuses on the distinct subtypes' roles in skin homeostasis, repair, and their evolution in fibrotic diseases like keloid scars and cancer.

In this study, researchers analyzing human fetal skin fibroblasts found eight distinct populations with developmental stage-specific abundance, identifying markers linked to fibroblast functions in blood vessel development, dermal layers, and hair follicle maturation.

This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.