Dermal Fibroblasts: Terminology, Heterogeneity of Subpopulations, and Common Properties

September 2021 in “ Morphologia ”

І. В. Твердохліб, Yu. V. Sіlkіna

dermal fibroblasts papillary dermal fibroblasts reticular fibroblasts hair follicles fibroblast-epidermal interactions cutaneous structural transformations

TLDR Dermal fibroblasts have at least three distinct types, each with unique roles in skin structure and hair development.

The document discussed the dynamic and diverse population of dermal fibroblasts in human skin, highlighting that mature skin contained at least three distinct subpopulations of fibroblasts located in specific dermal regions. These subpopulations, including papillary and reticular dermal fibroblasts, exhibited unique histophysiological differences when cultured separately. The study emphasized the role of fibroblasts in fibroblast-epidermal interactions during hair development and in interfollicular skin areas, as well as their significant contribution to structural skin remodeling.

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