Dermal Fibroblasts: Terminology, Heterogeneity of Subpopulations, and Common Properties

The document discussed the diverse and dynamic nature of dermal fibroblasts, highlighting that normal adult human skin contained at least three distinct subpopulations of these cells, each occupying unique niches in the dermis. It noted that papillary dermal fibroblasts, located in the superficial dermis, and reticular fibroblasts, found in the deep dermis, exhibited specific histophysiological differences. These subpopulations were distinct from fibroblasts associated with hair follicles. The study emphasized the role of fibroblasts in fibroblast-epidermal interactions during hair development and their importance in cutaneous structural transformations.