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Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Memory T cells in the skin balance staying put and moving into the blood, clustering around hair follicles, and increasing in number after infection.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

Women with PCOS have a higher risk of diabetes and heart problems, especially when they get older.

About 2.2% of women with symptoms of high male hormones have a mild form of congenital adrenal hyperplasia, and measuring a specific hormone level can accurately diagnose it.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Estrogen therapy can reduce skin aging but has cancer risks.

Laser hair removal effectiveness depends on targeting hair structures without harming the skin, and improvements require more research and expert collaboration.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.

K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.

Young adults have about 230,000 tactile nerve fibers, decreasing 5-8% per decade with age.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Keratose, derived from human hair, is a non-toxic biomaterial good for tissue regeneration and integrates well with body tissues.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Low fluence photoepilation temporarily removes hair by targeting the hair follicle's pigmented area without severe damage.

GABRA2 gene variations impact alcohol response, and hair loss medication finasteride reduces some effects.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.

Taking selenium supplements during chemotherapy may help reduce side effects and improve health markers in ovarian cancer patients.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

The BASP classification is a detailed and accurate way to categorize hair loss in both men and women.

Fat cells in the skin help start healing and form important repair cells after injury.

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

Many women in southern China have polycystic ovary syndrome, with some symptoms differing from Western women.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.