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Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Nerves are crucial for the regeneration of various body parts in many animals.

Eph receptors and ephrins may be promising targets for treating diseases, but more understanding is needed for effective and safe therapies.

PGD2 stops hair growth and is higher in bald men with AGA.

Some medicinal plants can help heal wounds and may lead to new treatments.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

MIM is crucial for hair follicle formation and regeneration by controlling cilia formation and hedgehog signaling through its interaction with Cortactin and Src.

Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

Tiny needles with valproic acid can effectively regrow hair.

Macrophages are vital for skin healing, hair growth, salt balance, and cancer defense.

Blocking the CXCR3 receptor reduces T cell accumulation in the skin and prevents hair loss in mice.

Prolactin affects the production of different keratins in human hair, which could lead to new treatments for skin and hair disorders.

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

Keratin 79 marks a new group of cells that are key for creating and repairing the hair follicle's structure.

Apoptosis is crucial for healthy skin and treating skin diseases.

The document concludes that while there are various treatments for Alopecia Areata, there is no cure, and individualized treatment plans are essential due to varying effectiveness.

Hair can regrow after certain stem cells are lost because other stem cells can take over their role.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.