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The document reviews key historical figures and discoveries in dermatology.

Polyomavirus A2 infection in newborn mice caused hair follicle tumors.

Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.

The document suggests that clinical trials for PCOS should focus on meaningful primary outcomes like live birth rates, rather than less reliable surrogate markers.

Loss of Fz6 disrupts hair follicle and associated structures' orientation.

In vivo confocal scanning laser microscopy is an effective, non-invasive way to study and measure new hair growth after skin injury in mice.

Eating less can improve stem cell function and increase lifespan.

Hair transplants are effective for male and female pattern baldness, have evolved in technique, and require careful planning for natural results and managing complications.

The document concludes that management strategies for PCOS are important due to its common occurrence and associated health risks.

Eating disorders are serious, often undiagnosed conditions requiring early treatment, with anorexia being the most deadly and binge-eating the most treatable.

Hair loss in African American women, caused by hair care, genetics, and environment, needs more research for better treatment.

Managing metabolic syndrome needs both lifestyle changes and medical treatments.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Childhood obesity is rising globally due to various factors, and early prevention and healthy lifestyle changes are crucial.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The Rotterdam Study aims to understand various diseases in older adults.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Voriconazole can cause serious side effects, especially in long-term use.

Obesity increases the risk of developing polycystic ovary syndrome, and weight loss can improve the condition.

The conclusion is that tissue structure is key for stem cell communication and maintaining healthy tissues.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Doctors need to be better prepared to assess and treat obesity in patients.