36 citations
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July 1996 in “The journal of investigative dermatology/Journal of investigative dermatology” This research reports a new autosomal recessive mutation in mice, 'lanceolate hair', causing generalized alopecia and hair shaft abnormalities, which may serve as a model for Netherton's syndrome in humans.
January 2000 in “The Mouseion at the JAXlibrary (Jackson Laboratory)” This study identified a new mouse mutation associated with noninflammatory proliferative skin disease and hair abnormalities, drawing parallels to human conditions like Netherton's syndrome and monilethrix.
September 2024 in “The Professional Medical Journal” This observational retrospective study conducted at Lahore General Hospital reported that scabies, followed by tinea and acne, were the most common skin diseases, primarily affecting females and prevalent in the summer months among the studied population.
July 2025 in “Pakistan Journal of Rehabilitation” This study observed that among Doctor of Physiotherapy students in Lahore, the prevalence of androgenetic alopecia was 55.6% in males and 60% in females, highlighting the need for better public education and early treatment strategies.
January 2025 in “Pakistan Journal of Health Sciences” This study found a weak association between Cyp11a1 gene variation and polycystic ovary syndrome, with higher di-hydro-testosterone levels observed in individuals with the syndrome and anovulatory PCOS compared to controls.
1 citations
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January 2023 This study found that patients with alopecia areata experience reduced quality of life, particularly among women and those with severe or long-lasting disease.
June 2021 in “Pakistan Journal of Medical and Health Sciences” This study found no association between the type of baldness, stress levels, and smoking status among male residents of Lahore.
81 citations
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March 2006 in “Journal of Investigative Dermatology” Mutations in the DSG4 gene cause specific hair and scalp issues.
74 citations
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January 2006 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified novel compound heterozygous mutations in the DSG4 gene in a Japanese patient with congenital hypotrichosis, suggesting overlap between localized autosomal recessive hypotrichosis and monilethrix.
61 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” This review discusses the causes, clinical presentation, and management of anagen effluvium, emphasizing its psychological impact and the need for empathy and practical support, but reports no new results.
50 citations
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February 2004 in “Genomics” This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.
46 citations
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October 2009 in “Archives of Dermatology” This study found that loose anagen hair syndrome is a common form of alopecia in young girls, typically presenting with thin, sparse hair and usually confirmed by a hair-pull test.
44 citations
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August 2004 in “Journal of Investigative Dermatology” A gene deletion in DSG4 causes sparse hair in some Pakistani families.
35 citations
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May 2006 in “Journal of Investigative Dermatology” Monilethrix involves multiple genes affecting hair structure, including DSG4 mutations.
33 citations
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October 2005 in “Journal of Investigative Dermatology” A specific gene mutation causes sparse, brittle hair in a family.
31 citations
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December 2010 in “Journal of the American Academy of Dermatology” This study reports that structural abnormalities in the inner root sheath of hair follicles may cause the hair shaft to be loosely attached in patients with loose anagen hair syndrome.
24 citations
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September 1997 in “PubMed” This study concludes that loose anagen hair can develop in adulthood and may be difficult to distinguish from telogen hair loss, with pathologic findings offering limited diagnostic insights.
18 citations
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March 2015 in “Journal of Dermatological Case Reports” This study identified distinctive trichoscopic features that may aid in diagnosing loose anagen hair syndrome, such as rectangular black granular structures, solitary yellow dots, and a predominance of follicular units with single hairs.
13 citations
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August 2005 in “Journal of Investigative Dermatology Symposium Proceedings” This study describes a genetic mutation in the desmoglein 4 gene linked to localized autosomal recessive hypotrichosis in Pakistani families, showing similarities to animal models with similar hair loss conditions.
13 citations
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March 2014 in “Pediatric Dermatology” This case report observed that a 2-year-old girl with loose anagen hair syndrome experienced rapid and significant improvement without adverse effects from tapered minoxidil 5% treatment over 28 months.
12 citations
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June 2009 in “Journal of Cosmetic Dermatology” This study reports the first cases of loose anagen hair syndrome in dark-skinned children from Upper Egypt, noting it may be under-diagnosed and primarily causes cosmetic concerns without affecting general health.
9 citations
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December 2020 in “British Journal of Dermatology” This research letter reports that low-dose oral minoxidil improved hair density and length in children with loose anagen hair syndrome.
8 citations
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August 2013 in “Pediatric Dermatology” This article reviews loose anagen hair syndrome, an inheritable hair disorder affecting children and sometimes adults, but does not report any new clinical results.
4 citations
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April 2018 in “The journal of pediatrics/The Journal of pediatrics” This case report discusses a 6-year-old girl with loose anagen hair syndrome, characterized by painlessly shedding hair, and notes no evidence of benefit from biotin supplementation.
3 citations
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May 2024 in “Cureus” This study found that LAHR significantly improves the quality of life in the short term for women with PCOS, but underscores a need for further research to develop long-term treatment strategies.
2 citations
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July 2019 in “Indian dermatology online journal” This report documents a rare case of familial eyelash trichomegaly and synophrys in three siblings, with one sister also having loose anagen hair syndrome, an unreported association.
2 citations
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August 2012 in “Journal of the American Academy of Dermatology” This correspondence describes two patients with both epidermolysis bullosa simplex, Dowling-Meara type, and loose anagen hair syndrome, an association not previously reported in the literature.
1 citations
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April 2016 in “Journal of The American Academy of Dermatology” This study found that patients with androgenetic alopecia experienced more severe symptoms than those with alopecia areata, influencing their quality of life differently based on various patient characteristics.
1 citations
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February 2013 in “InTech eBooks” Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.
May 2023 in “International journal of science and research” This case report describes two boys aged 8 and 10 with loose anagen hair syndrome who experienced successful hair regrowth using topical minoxidil 2% solution, suggesting it may be an effective initial treatment option for severe cases of this condition.