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In this study, the authors found that targeting mTORC1 with rapamycin inhibited TPA-induced skin tumor promotion by affecting keratinocyte proliferation, including critical stem cell populations in the mouse epidermis.

This review discusses botulinum toxin's experimental off-label uses in dermatology, highlighting promising results but emphasizing the need for more clinical trials to confirm efficacy and safety.

This study provides evidence-based recommendations for the off-label use of topical vitamin D in treating certain skin conditions, but highlights the need for higher quality studies for further validation.

This study discusses the role of physicians and pharmaceutical companies as entrepreneurial actors in off-label drug use, arguing they may advance patient care more quickly than regulatory agencies.

This review discusses the off-label uses of retinoids in dermatology, focusing on oral isotretinoin and acitretin, and reports no new clinical results.

This correspondence about the treatment of chronic alopecia areata with tildrakizumab reports no clinical results; the authors present an open-label pilot study setup.

In this open-label study, 80% of participants with androgenetic alopecia showed improvement after taking the oral supplement Forti5® for 24 weeks, with significant increases in hair mass index and terminal hair count.

This study found that Asthimajjapachak Churna provided significantly more therapeutic relief from hair fall than Shwadamshtradi Rasayana Churna in young females over 30 days.

This study reviewed various studies and concluded that Janus kinase inhibitors, particularly tofacitinib, seem to promote hair regrowth in about half of patients with alopecia areata, though expected class-specific adverse effects were observed.

This article narrates a case where a patient with androgenetic alopecia faced high out-of-pocket costs for finasteride 1 mg and sought to reduce expenses by requesting a prescription for 5 mg tablets typically used for BPH, which are covered by insurance.

This study found that Secretory Phospholipase A2-IIA (sPLA2-IIA) promotes proliferation through JNK/c-Jun signaling, distinctively affecting normal stem cells and cancer cells, suggesting it as a potential target for cancer treatment.

This study identified significant trends in interest around selective androgen receptor modulators, with increasing attention contrasting stagnant or declining interest in post-cycle therapies and anabolic steroids, and calls for clinicians to use social and prescription data to adjust treatment protocols accordingly.

This article discusses the issues with the name "polycystic ovary syndrome" and proposes a new naming system to better reflect the condition's complex hormonal and metabolic abnormalities.

ASLAN004 was safe and well-tolerated, supporting further development for treating certain diseases.

This study observed that insurance coverage for oral tofacitinib in alopecia areata patients was difficult to obtain, with 71% of patients ultimately not receiving approval despite the drug's efficacy as an off-label treatment.

This study found that adipose-derived stem cell exosome injections were more effective than minoxidil in improving hair density and diameter in patients with androgenetic alopecia, with high patient satisfaction and manageable side effects.

In this study, tofacitinib showed a mixed response in treating refractory alopecia areata, with some patients experiencing complete or partial hair regrowth and others showing no response, particularly those with alopecia universalis.

Trichoscopy is a helpful and quick method to diagnose hair loss without shaving.

In this study, researchers found that EqualsTwo Oil Free Hair Oil significantly reduced hair fall by up to 73.8% and improved hair strength, scalp condition, and growth cycle parameters in pregnant and lactating women over a 30-day period, without adverse effects.

This clinical study found that using a cream or lotion as an additional treatment alongside standard care for atopic dermatitis significantly reduced symptoms and improved skin moisturization and barrier function within 28 days compared to standard care alone in participants with mild-to-moderate eczema.

This study found that a hair serum containing Acanthus ebracteatus extract improved hair regrowth in men with androgenic alopecia, increasing hair count and density of anagen hairs over a 6-month period, with combination treatments showing early effectiveness.

In this study, researchers found that connexin 43-negative cells in the basal layer of the epidermis could serve as markers for keratinocyte stem cells, aiding their identification and separation.

This article reviews the biology of epithelial stem cells and their role in tissue self-renewal, maintenance, and regeneration, and it highlights the clinical implications of understanding their signaling pathways, but it presents no new clinical findings.

New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.

This study found that the CD44(+) ALDH(+) population of neonatal human keratinocytes exhibited enhanced stem cell properties, including significantly increased long-term epidermal regeneration and multipotency, compared to unfractionated cells.

In this study, researchers identified slow cycling label retaining cells in nail and sweat gland appendages, showing stem cell characteristics similar to hair follicles but with distinct features.

This study found that after a health warning, off-label flutamide use by women reduced significantly in Spain, although misuse among ambulatory patients remains an issue.

Finasteride must now warn about lasting sexual side effects.

This study found that hair membrane fluidity is low in the cuticle but high in the cortex and medulla, with treatments like ionic surfactants and oleic acid increasing fluidity in hydrated hair; however, dehydration significantly reduces fluidity throughout the hair.

This study demonstrated that an automated algorithm can effectively track epithelial cell movement within clusters, revealing that partial knockdown of E-cadherin reduces electrotactic potential in breast epithelial cells, particularly in free-moving clusters, and suggesting an adhesion-independent role of E-cadherin in regulating cell electrotaxis.