Characterization of New Stem/Progenitor Cells in Skin Appendages

    July 2013 in “ University of Southern California Digital Library ”
    Yvonne Leung
    TLDR New stem cells in nails and sweat glands can regenerate skin and hair.
    The study identified slow cycling label retaining cells (LRCs) in the sweat gland and nail skin appendages, which exhibited stem cell characteristics similar to those of hair follicle stem cells. These LRCs were localized to specific regions in the nails and sweat glands and expressed K15, a known hair follicle stem cell marker. Lineage tracing experiments indicated their long-term self-renewal capabilities. Gene expression profiling revealed BMP pathway signaling genes in both appendages, and functional experiments demonstrated the necessity of Bmpr1a-mediated signaling. The findings suggested that sweat gland LRCs could differentiate and contribute to the epidermis during prolonged wound healing, and transplantation experiments indicated their potential plasticity in regenerating sweat glands and hair follicles. The study concluded that these LRCs might serve as putative stem cell markers for human nails and sweat glands, although further research was needed for comprehensive characterization.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 594 results

      community PP405 could be released before GTA 6

      in Chat  133 upvotes 2 months ago
      PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.

      community A Theory on Why Microneedling Works

       172 upvotes 6 years ago
      Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  91 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Similar Research

    6 / 1000+ results