September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identifies two previously unreported pathogenic RIPK4 gene variants, suggesting a functional link with cell adhesion molecules in ectodermal dysplasias.
In this research, the author hypothesizes that curly hair is influenced by the contraction of the Arrector Pili muscle, suggesting that its relaxation through specific treatments could potentially modulate hair follicle curvature, but further studies are needed to confirm this mechanism.
13 citations
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October 2008 in “PubMed” This study examined hair curvature in Japanese women, finding that 47% have curved hair, and identified structural differences in hair fiber, which resemble those in wool fibers.
26 citations
,
February 1991 in “PubMed” This case report highlights trichotillomania's distinguishing "tonsure pattern" and nail-biting, emphasizing the need to differentiate it from other hair loss types due to differing treatments.
13 citations
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January 2012 in “International journal of trichology” This case study describes a 14-year-old girl with pili annulati who had fragile hair, which may be due to cavities within the hair shafts as seen in electron microscopic examinations.
8 citations
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July 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the tensile strength of curly hair is influenced by two main components, with springiness (toe region) contributing significantly, unlike in noncurly hair where it is negligible.
March 2018 in “Journal of Experimental Biology” This study found that the curl in hair is due to the arrangement of different cell types, with shorter paracortical cells inside the curve and longer orthocortical cells outside.
65 citations
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May 2006 in “Journal of Structural Biology” This study concluded that the curliness of human hair, regardless of ethnicity, originates from the inhomogeneous internal nanostructure due to differences in the distribution of two types of cortices.
February 2024 in “Journal of Dermatological Science” This study examined the formation of acquired curved hair and found that the fusion of hair matrix cells during follicle regeneration contributes to asymmetric follicle shapes and curved hair, potentially linked to changes in type IV collagen and protein expression levels.
8 citations
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December 2003 in “Experimental Dermatology” In this study, injecting chimeric RNA–DNA oligonucleotides into mice skin caused a temporary mutation in keratin 17, altering hair morphology, but the mutation was transient due to genetic compensation or cell replacement.
4 citations
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July 2010 in “International Journal of Cosmetic Science” This study observed that hair fibers in older women become more curved with age, decreasing hair luster due to their disordered alignment and structural differences between the convex and concave sides.
17 citations
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December 2009 in “Journal of Pediatric Orthopaedics” This report describes two cases of toe tourniquet syndrome in infants, highlighting the importance for pediatric orthopedic practitioners to diagnose and manage it promptly, suggesting a specific incision method to release hair strangulation if removal is challenging.
1 citations
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July 1935 in “Nature” This study found super-contraction in the guard hairs of fur-bearing animals, likely due to oxidation in living animals, primarily affecting white and red foxes without prior heat or chemical treatment.
November 2024 in “Biophysical Chemistry” This study analyzed the swelling behavior of human hair during permanent waving treatment, finding that both the microstructure and macrostructure of intermediate filaments swell simultaneously at the initial stage, and while partially destructed by reduction, they are considerably restored through oxidation.
Mutations in keratin genes may link hair disorders to dental decay.
1 citations
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March 2023 in “Journal of Natural Fibers” This study explored using tyrosine as a cross-linking agent for curling Asian hair and found that it could shape hair effectively before washing without damaging the fibers, though the method was less effective after washing compared to commercial products.
August 2022 in “Archives of pediatric surgery” This article reviews cultural differences in the incidence of hair-thread tourniquet syndrome and finds it may be less prevalent in Iranian children compared to Europe, possibly due to social and cultural factors.
7 citations
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November 2017 in “Cureus” This report introduces a new potential sign, paired ear creases of the helix, which may have relevance to cardiovascular disease similar to diagonal ear lobe creases, in a case of coronary artery disease.
8 citations
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June 2016 in “Journal of Pediatric Orthopaedics B” This paper presents two cases of hair tourniquet syndrome and suggests washing baby socks inside out as a potential preventative measure.
6 citations
,
February 2013 in “Veterinary Dermatology” This case report describes the first documented occurrence of pili torti in a healthy young adult cat, marked by noninflammatory and nonpruritic symmetrical multifocal alopecia.
2 citations
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May 2022 in “International journal of trichology” This article reviews the condition plica neuropathica, including its manifestations, potential causes, and treatment, but it does not provide new clinical findings.
July 2022 in “Journal of Investigative Dermatology” This study found that Dkk4-knockout mice exhibited disrupted hair follicle patterning, including a lack of the first wave of hair follicles in the lateral back skin.
13 citations
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January 2001 in “Pediatric dermatology” This study reports pseudopili annulati in a dark-haired Chinese girl, identifying the unique appearance and structural characteristics of her hair without finding abnormalities in the cuticle and cortex.
114 citations
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February 2023 in “International Journal of Molecular Sciences” This review discusses the relationship between skin microbiome changes and conditions such as ageing and skin disease, emphasizing the need for further research, but reports no new findings.
88 citations
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May 2024 in “Journal of Extracellular Vesicles” This scoping review found that while some small human pilot trials of extracellular vesicles as therapeutics showed promising outcomes, variability in study design and lack of placebo controls limit definitive conclusions about their safety and efficacy.
59 citations
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August 2021 in “Frontiers in Endocrinology” This review discusses the roles and therapeutic effects of GLP-1 receptor agonists on the nervous, cardiovascular, and endocrine systems, but reports no new clinical results, emphasizing the need for further research on their impact on metabolism and tumor relationships in type 2 diabetes patients.
52 citations
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March 2022 in “Biology of Sex Differences” This review examines biological reasons for sex-based differences in COVID-19 outcomes, noting that females exhibit stronger immune responses, potentially explaining lower severity and mortality compared to males.
35 citations
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March 2010 in “BMC veterinary research” The study found that while a clinical protocol showed high specificity in detecting scrapie in goats, its low sensitivity suggests many cases might be missed if diagnosis is only based on clinical signs.
22 citations
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May 2019 in “Animals” In this study, researchers found that high hair cortisol levels, indicating stress in cows, were associated with certain shelter and cow-level conditions such as unclean environments and physical injuries.
4 citations
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November 2024 in “International Journal of Molecular Sciences” This review explores whether SARS-CoV-2 could trigger or worsen α-synucleinopathies, like Parkinson's disease, by affecting α-synuclein misfolding and aggregation, potentially linking COVID-19 with the development of parkinsonism-like symptoms.