1 citations
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July 2024 in “Nanomedicine” This study demonstrated that EVs from pluripotent stem cell-derived mesenchymal stem cells improved recovery and function in ischemic lower limbs by enhancing angiogenesis through the ERK/MAPK signaling pathway.
1 citations
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November 2020 This study found that a pro-fibrotic Wnt1/βcatenin injury response is crucial for maintaining cardiac function following acute ischaemic cardiac injury by activating the epicardium and cardiac fibroblasts.
December 2025 in “Scientific Reports” This study found that preconditioning human hair follicle-derived stem cells with valproic acid enhanced their survival and migration in ischemic-like conditions by activating autophagy and inhibiting the AKT/mTOR pathway, suggesting this approach could improve stem cell therapies for ischemic stroke.
January 2025 in “Acta Clinica Croatica” This pilot study found that using platelet rich fibrin in combination with dressings after revascularization surgery in patients with critical limb ischemia accelerated wound healing compared to dressings alone.
44 citations
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October 2017 in “Scientific Reports” This study found that far-infrared radiation preconditioning significantly enhanced the proliferation, survival, and migration of bone marrow-derived stem cells in vitro, indicating potential therapeutic benefits for cardiac ischemia treatment.
6 citations
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October 2018 in “Lasers in Medical Science” This article explores the potential of photobiomodulation for coronary health, suggesting protective effects after heart attacks and in inaccessible ischemic heart conditions, but presents no new clinical results.
3 citations
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July 2024 in “Animals” This study reported that tail tip lesions in dairy cows include granulation tissue, purulent-necrotizing inflammation, and hyperkeratosis, potentially caused by ischemia.
May 2026 in “Pharmaceuticals” This study analyzed safety data for semaglutide, liraglutide, and tirzepatide from the EudraVigilance database, identifying potential safety signals not listed in current SmPCs, such as optic ischemic neuropathy and pancreatitis, underscoring the importance of ongoing pharmacovigilance.
August 2025 in “Frontiers in Immunology” This meta-analysis found that patients with alopecia areata, particularly those with more extensive forms like alopecia totalis and universalis, may face a higher risk of cardiovascular disease, though no links were found with specific conditions like ischemic stroke or myocardial infarction.
May 2025 in “Neuropharmacology” This study in neonatal rats found that inhibiting neurosteroid synthesis with finasteride unexpectedly reduced the severity and duration of neonatal seizures following birth asphyxia, maintained cognitive functions, but increased anxiety-like behaviors, highlighting a complex role of neurosteroids in hypoxic-ischemic encephalopathy outcomes.
March 2025 in “Journal of Cosmetic Dermatology” The study found that botulinum toxin-A significantly increased the diameter of the supratrochlear artery in a small patient group, suggesting potential vasodilatory benefits for treating ischemic conditions.
This study reports an increase in the frequency and variety of skin conditions associated with COVID-19, noting that milder cases often present with pernio-like lesions, while severe cases may involve livedo racemosa, retiform purpura, and acral ischemia.
27 citations
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February 2020 in “EMBO Reports” This study concluded that MEX3A is critical for maintaining Lgr5+ intestinal stem cells by regulating the PPARγ pathway, impacting intestinal homeostasis during postnatal development in mice.
91 citations
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December 2019 in “The EMBO Journal” This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.
1 citations
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April 2022 in “Frontiers in Bioengineering and Biotechnology” This study found that mouse astrocytes formed cell spheres on agarose surfaces, acquired stem cell-like features, and their derived stem cells effectively differentiated into neurons that helped regenerate damaged nerves.
April 2023 in “American Journal of Transplantation” This study found that hormone replacement therapy was associated with reduced COVID-19 mortality and adverse outcomes in nonimmunosuppressed postmenopausal women and immunocompromised male solid organ transplant recipients.
Finasteride may reduce heart damage in rats.
298 citations
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January 2014 in “BioMed Research International” This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.
74 citations
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February 2018 in “Stroke” This review discusses unique stroke risk factors in women, such as hormonal and reproductive influences, and highlights the need for further research to better predict and manage these risks.
40 citations
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November 2021 in “npj Regenerative Medicine” In this study, spiny mice showed superior cardiac recovery after myocardial infarction compared to other mouse strains, with enhanced myocardial preservation and functional stabilization.
37 citations
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March 2005 in “Journal of Paediatrics and Child Health” This case report and review discuss hair-thread tourniquet syndrome in a 14-year-old autistic child, highlighting its rarity and the misconception of it being linked to abuse or socio-cultural practices.
33 citations
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March 2018 in “Trends in cell biology” This review summarizes evidence suggesting that metabolism actively influences stem cell fate in intestinal and hair follicle stem cells, rather than being a mere environmental byproduct.
25 citations
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December 2001 in “Expert Opinion on Pharmacotherapy” This review discusses the therapeutic potential of potassium channel openers for various conditions, but notes that their clinical role is not yet fully established.
13 citations
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September 2014 in “BMC Complementary and Alternative Medicine” Tanshinone IIA helps protect skin tissue from low oxygen damage by boosting certain cell markers.
5 citations
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November 2022 in “Molecular Neurobiology” Melatonin may protect inner ear cells from damage by reducing cell death and oxidative stress, potentially treating sudden hearing loss.
3 citations
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May 2020 in “Journal of Cellular and Molecular Medicine” This study identified critical roles for the gene GREM1 in the differentiation and expansion of endothelial progenitors derived from human urinary induced pluripotent stem cells.
2 citations
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July 2023 in “Urology Case Reports” This case report highlights an 11-month-old boy with near total amputation of the glans penis due to Penile Hair Tourniquet Syndrome, who underwent successful two-stage surgical repair for a satisfactory outcome.
1 citations
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September 2023 in “Frontiers in Genetics” This study presents a rare case where a patient with a heterozygous mutation in the HTRA1 gene, typically considered non-pathogenic, exhibited severe symptoms and typical features of CARASIL, expanding the understanding of this condition.
July 2025 in “Microscopy and Microanalysis” In this research, scientists developed a compression therapy model using immobilized mice, successfully analyzing skin without causing injury, and observed increased epidermal thickness and changes in adipocyte volume, with no increase in DNA damage markers.
This review discusses the complex causal relationships between testosterone exposure and various health outcomes, but notes that the studies reviewed show substantial heterogeneity.