Large Extracellular Vesicles From Induced Pluripotent Stem Cell-Marrow Stem Cells Enhance Limb Angiogenesis Via ERK/MAPK

July 2024 in “ Nanomedicine ”

Ziyu Huang, Zhengsheng Chen, Teng Ye, Lei Luo, Juntao Zhang, Qing Li, Yang Wang, Bizeng Zhao

TLDR Stem cell-derived vesicles improve blood vessel growth in limbs.

This study investigated the effects of large extracellular vesicles (EVs) derived from induced pluripotent stem cell-mesenchymal stem cells (iMSCs) on lower limb ischemic disease. The results showed that iMSCs-lEVs alleviated injury and improved recovery of lower limb function by promoting endothelial cell angiogenesis through the ERK/MAPK signaling pathway. In vitro experiments demonstrated that iMSCs-lEVs enhanced the proliferation, migration, and angiogenesis of HMEC-1 cells, highlighting their potential therapeutic role in treating ischemic conditions.

View this study on pmc.ncbi.nlm.nih.gov →

Large Extracellular Vesicles From Induced Pluripotent Stem Cell-Marrow Stem Cells Enhance Limb Angiogenesis Via ERK/MAPK

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