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Some existing drugs and natural products might work against COVID-19 by targeting the virus's main protease.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

A gene called APCDD1, which controls hair growth, is found to be faulty in a type of hair loss called hereditary hypotrichosis simplex.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Fungi-produced compounds can change plant root growth.

Some medicinal plants can help heal wounds and may lead to new treatments.

Use minoxidil for hair loss treatment; assess results after 6 months.

Finasteride effectively treats baldness but may cause sexual side effects.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

The Wnt/β-catenin pathway is important for tissue development and has potential in regenerative medicine, but requires more research for therapeutic use.

The genus Sophora has compounds with potential health benefits and could lead to new drugs, but more research is needed to understand their effects and safety.

The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

Jasmonic acid and its derivatives play important roles in plant health and have potential uses in medicine and agriculture.

Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.

Finasteride works better than Permixon in reducing dihydrotestosterone levels.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Human hair follicles produce and respond to erythropoietin, helping protect against stress.

Janus kinase inhibitors are promising drugs for treating autoimmune and inflammatory diseases.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Wnt signaling is crucial for skin wound healing and reducing scars.

Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

Both drugs lower DHT levels, with GI198745 being more effective.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.