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Direct vasodilators and sympatholytic agents are still useful for certain conditions despite being less common due to side effects and newer drugs.

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

Photobiomodulation therapy helps manage cancer treatment side effects but needs more research for optimization.

Alopecia Areata (AA) causes significant emotional distress, including feelings of embarrassment, depression, and anxiety, and impacts social interactions and daily activities.

The review suggests new ways to classify ejaculation problems and recommends different treatments based on the type of issue.

Blue light can help treat skin conditions like eczema and acne without major side effects.

Scaffold-based strategies show promise for regenerating hair follicles and teeth but need more research for clinical use.

Thiazole, a sulfur and nitrogen chemical, is useful in creating potential drugs for conditions like seizures, cancer, bacterial infections, tuberculosis, inflammation, malaria, viruses, Alzheimer's, diabetes, and A1-receptor issues.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

Botulinum and tetanus neurotoxins are better understood now, with updated information on their effects and treatment.

Natural volatiles and essential oils have health benefits and can enhance the effects of some medicines, but more research is needed to understand how they work and their possible side effects.

Hormone therapy increases the risk of heart-related issues in transgender women and may affect heart health in transgender men.

Growth hormone levels affect hair growth and loss, with too much causing excess hair and too little leading to hair loss.

Alopecia areata can be managed with various treatments, and severe cases should be referred to dermatologists.

There is a significant need for better-validated quality of life tools in dermatology.

Microbial biosurfactants could be a safer and environmentally friendly alternative to chemical surfactants in cosmetics.

Alopecia areata greatly affects people's life quality, mental health, and work life.

Synthetic antioxidants are effective, cheap, and stable, with some like zinc and cholecalciferol reducing child and cancer deaths, but the safety of additives like BHA, BHT, TBHQ, and PEG needs more research.

Poor body image from pain can lead to more depression in lupus patients.

Piezoelectric Nanogenerators are promising for non-invasive health monitoring but need efficiency and durability improvements.

Patients with long COVID after Omicron had fewer hospitalizations and milder symptoms but more fatigue, insomnia, and cough compared to those with Delta.

Accurate diagnosis and various treatments can rejuvenate the upper face for a natural look.

SIM01 significantly reduced post-COVID symptoms and is safe.

Baricitinib, a drug for rheumatoid arthritis, atopic dermatitis, and alopecia areata, is generally safe with low risk of major side effects, even in patients with risk factors. It's also effective in promoting hair regrowth in alopecia areata patients.

Combining yoga and certain herbs can effectively manage PCOS symptoms and improve quality of life.

Hormone imbalance is linked to Hidradenitis Suppurativa, a skin condition, and treatments like anti-androgenic therapy and metformin can help. It's also suggested to check patients for insulin resistance and Polycystic Ovary Syndrome.

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

Neurotoxins can affect neurotransmitter release and have potential in treating muscle, pain, and cancer conditions, but more research is needed on how they work.

Polycystic ovary syndrome, a disorder causing menstrual issues and infertility, can be treated with lifestyle changes, medication, herbal remedies, surgery, and assisted reproductive techniques like artificial insemination and IVF.

The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.