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This paper discusses two preclinical models for studying alopecia areata and finds that testing new therapeutic agents should involve both the C3H/HeJ mouse model and the humanized mouse model for comprehensive insights.

This study reports a novel mutation in the TP63 gene associated with T and B cell lymphopenia in an EEC patient, suggesting that EEC diagnosis should include TREC assay and evaluation for immunodeficiency.

This article reviews the role of vitamin D in regulating immune responses related to autoimmune diseases like alopecia areata, but it presents no new clinical findings.

This study found that despite the persistence of aberrant double-negative T-cells, functional immune-competence was maintained after thymic transplantation in a patient with a rare FOXN1 mutation.

This review highlights that malnutrition, including deficiencies in proteins and micronutrients, may exacerbate allergic conditions like dermatitis and asthma by promoting inflammation, while adequate micronutrient intake supports regulatory immune responses.

In this case-control study, individuals with alopecia areata showed significantly elevated levels of inflammatory markers IL-4, IFN-γ, and CRP, as well as reduced serum Folate and Ferritin, suggesting the condition's multifactorial pathophysiology involves immune activation, systemic inflammation, and micronutrient deficiencies.

This fact sheet discusses the impacts of zinc deficiency, including its effects on the immune system, cognitive function, and growth in children, and highlights the increased risk for those who consume alcohol excessively; it reports no new clinical results.

This study developed a foxn1-deficient Xenopus laevis model using CRISPR/Cas9, observing reduced T-cell markers and altered immune responses in tadpoles, providing a nonmammalian model for immunological research.

This study found that Wnt secretion is important for maintaining skin homeostasis in mice, as Evi-deficient mice developed psoriasis-like skin lesions and had an imbalance in immune cell populations.

This study discusses the potential association between low vitamin D levels and insulin resistance, suggesting that vitamin D deficiency may contribute to disorders like obesity and diabetes, but emphasizes the need for further research to confirm these links.

In this study, researchers using a Treg-specific HuR-deficient mouse model found that the RNA-binding protein HuR is crucial for stabilizing Foxp3 mRNA, affecting Treg function and immune regulation, with HuR disruption leading to impaired Foxp3 expression and potential autoimmune dysfunction.

This research highlights selenium's critical roles in various biological processes and underscores the potential health impacts of both its deficiency and excess, including increased mortality risk, poor immune function, and neurological issues.

This paper offers a detailed overview of B vitamins, detailing their importance for energy, cognition, and metabolism, conditions leading to their deficiencies, symptoms of deficiencies, and the foods rich in these essential nutrients.

This review discusses the biochemical and psychological impacts of polycystic ovary syndrome on immune functions against COVID-19 but reports no new clinical results.

This study found that Wnt secretion is important for skin homeostasis in mice, as Evi-deficient mice developed skin lesions resembling psoriasis and showed immune cell imbalance.

This review outlines the diagnosis and management of folliculitis decalvans, an inflammatory scalp disorder, and highlights Staphylococcus aureus and immune response deficiencies as key factors in its development.

This study found that iron therapy improved nonhematological symptoms and cognitive function in women with iron deficiency anemia, highlighting the need for attention to these symptoms in improving quality of life.

This article discusses the diagnostic and therapeutic approach for immune-mediated central nervous system diseases but reports no new clinical findings.

This study introduced the Vitamin Deficiency Detection System, which helps users identify potential vitamin deficiencies by analyzing symptoms they select on a user-friendly interface.

This review paper examined recent research on the biofortification of horticultural plants, such as fruits and vegetables, with selenium, highlighting their role in addressing selenium deficiencies and supporting various biological functions crucial to human health.

Propylthiouracil, a thyroid medication, can cause skin blood clots and immune-related blood vessel inflammation.

This study suggests that vitamin D and calcium signaling are crucial for normal wound healing, with deficiencies in these pathways potentially delaying recovery due to diminished stem cell activity and response.

This study found that disrupting inflammasome signaling by eliminating caspase-1 and -11 in mice reduced skin inflammation and delayed the onset of disease, highlighting their role in skin disease pathogenesis.

Patients with GATA2 deficiency show early skin symptoms that help diagnose the condition.

This article reviews the potential of Acyzol, a zinc-containing drug, to treat and prevent zinc deficiency conditions, but it reports no new clinical findings.

This paper presents a case where vitamin D replacement therapy was associated with hair regrowth in a patient with nonscarring alopecia linked solely to vitamin D deficiency and discusses managing vitamin D deficiency more broadly.

This article discusses the role of regulatory T cells in alopecia areata, where their deficiency in hair follicles may lead to impaired local immunity and suggests potential therapies like CAR-T reg cells and low-dose IL-2 to alleviate autoimmunity and promote hair regeneration in affected individuals.

This review discusses the etiology and pathogenesis of alopecia areata in children, highlighting the roles of heredity, immune factors, lipid peroxidation violations, microcirculation issues, and vitamin D deficiencies but reports no new clinical results.

This study found that patients with alopecia, particularly alopecia areata and female pattern hair loss, often have vitamin D deficiency, suggesting that screening for vitamin D could benefit these patients.

This study analyzed pediatric and adult patients with antibody deficiencies at a PID center, finding frequent severe infections and genetic mutations, with treatment primarily involving IVIG replacement therapy.